Tài liệu miễn phí Y khoa - Dược
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Improving colposcopic accuracy for cervical precancer detection: A retrospective multicenter study in China
Colposcopy alone can result in misidentification of high-grade squamous intraepithelial or worse lesions (HSIL+), especially for women with Type 3 transformation zone (TZ) lesions, where colposcopic assessment is particularly imprecise. This study aimed to improve HSIL+case identification by supplementing referral screening results to colposcopic findings.
4/9/2023 11:46:15 PM +00:00
Phase III randomised controlled trial on PSMA PET/CT guided hypofractionated salvage prostate bed radiotherapy of biochemical failure after radical prostatectomy for prostate cancer (PERYTON-trial): Study protocol
Salvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year biochemical progression-free survival up to 60%. Multiple studies have shown that dose escalation to the primary prostate tumour improves treatment outcome.
4/9/2023 11:46:08 PM +00:00
Machine learning algorithms to estimate 10-Year survival in patients with bone metastases due to prostate cancer: Toward a disease-specific survival estimation tool
Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate survival duration after treatment for skeletal-related events (SREs) (symptomatic bone metastasis, including impending or actual pathologic fractures) in men with metastatic bone disease due to prostate cancer.
4/9/2023 11:46:01 PM +00:00
Systemic treatment in patients with malignant pleural mesothelioma – real life experience
Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural cavity linked to asbestos exposure. The combination of pemetrexed and platinum is a standard first-line therapy for malignant pleural mesothelioma. Despite some progress, almost all MPM patients experience progression after first-line therapy.
4/9/2023 11:45:55 PM +00:00
Four cycles of R-CHOP followed by two applications of rituximab based on negative interim PET/CT: An analysis of a prospective trial
R-CHOP with or without radiotherapy is the standard treatment for limited-stage diffuse large B-cell lymphoma (DLBCL). To prevent overtreatment, we assessed whether four cycles of CHOP plus six applications of rituximab was adequate with negative interim PET/CT and the role of consolidation radiotherapy specifically for patients with Waldeyer’s ring DLBCL.
4/9/2023 11:45:42 PM +00:00
The prognostic potential of alkaline phosphatase and lactic acid dehydrogenase in bmCRPC patients without significant PSA response under enzalutamide
In patients with bone metastatic castration-resistant prostate cancer (bmCRPC) on systemic treatment, it is difficult to differentiate between continuous rise of prostate-specific antigen (PSA) representing progression, and PSA-surge, which is followed by clinical response or stable disease.
4/9/2023 11:45:35 PM +00:00
Modular and mechanistic changes across stages of colorectal cancer
While mechanisms contributing to the progression and metastasis of colorectal cancer (CRC) are well studied, cancer stage-specific mechanisms have been less comprehensively explored. This is the focus of this manuscript.
4/9/2023 11:45:26 PM +00:00
Tivozanib in renal cell carcinoma: A systematic review of the evidence and its dissemination in the scientific literature
Tivozanib (Fotivda) is an anti-angiogenic tyrosine kinase inhibitor that was denied access to the US market by the Food and Drug Administration (FDA). In contrast, it was granted approval by the European Medicines Agency (EMA) for the treatment of Renal Cell Carcinoma in adults.
4/9/2023 11:45:19 PM +00:00
Clinicopathological and ultrasound features as risk stratification predictors of clinical and pathological nodal status in papillary thyroid carcinoma: A study of 748 patients
Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid malignancy that tends to metastasize to cervical lymph nodes. In the present study, we aimed to investigate which clinicopathologic and ultrasound features of PTC are associated with clinical lymph node metastasis (LNM) and numbers of pathological LNM.
4/9/2023 11:45:13 PM +00:00
Association of a novel 27-gene immuno-oncology assay with efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer
Immune checkpoint inhibitor (ICI) therapies represent a major advance in treating a variety of advanced-stage malignancies. Nevertheless, only a subset of patients benefit, even when selected based on approved biomarkers such as PD-L1 and tumor mutational burden.
4/9/2023 11:45:05 PM +00:00
Irinotecan plus temozolomide in relapsed Ewing sarcoma: An integrated analysis of retrospective studies
The prognosis of patients with relapsed Ewing sarcoma is poor. In this study, we aimed to pooledanalyze the efficacy and safety of the combination of irinotecan and temozolomide in treating patients with relapsed Ewing sarcoma.
4/9/2023 11:44:53 PM +00:00
High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic cancer
Accumulation of the signal adaptor protein p62 has been demonstrated in many forms of cancer, including pancreatic ductal adenocarcinoma (PDAC). Although data from experimental studies suggest that p62 accumulation accelerates the development of PDAC, the association between p62 protein expression and survival in PDAC patients is unclear.
4/9/2023 11:44:46 PM +00:00
The circular RNA circFARSA sponges microRNA-330-5p in tumor cells with bladder cancer phenotype
Circular RNAs (circRNAs) modulate gene expression in various malignancies. However, their roles in the occurrence of bladder cancer (BC) and their underlying mechanisms of action are currently unclear.
4/9/2023 11:44:37 PM +00:00
HOX and PBX gene dysregulation as a therapeutic target in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival rates of 5%, a figure which has not improved over the last few decades.
4/9/2023 11:44:30 PM +00:00
A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells
The combined application of immune cells and specific biomarkers related to the tumor immune microenvironment has a better predictive value for the prognosis of HCC. The purpose of this study is to construct a new prognostic model based on immune-related genes that regulate cross-talk between immune and tumor cells to assess the prognosis and explore possible mechanisms.
4/9/2023 11:44:20 PM +00:00
The rationale for treating uveal melanoma with adjuvant melatonin: A review of the literature
Uveal melanoma is a rare form of cancer with high mortality. The incidence of metastases is attributed to early seeding of micrometastases from the eye to distant organs, primarily the liver. Once these seeded clusters of dormant tumor cells grow into larger radiologically detectable macrometastases, median patient survival is about 1 year.
4/9/2023 11:44:10 PM +00:00
Supportive oncology care at home interventions: Protocols for clinical trials to shift the paradigm of care for patients with cancer
Patients with cancer often endure substantial symptoms and treatment toxicities leading to high healthcare utilization, including hospitalizations and emergency department visits, throughout the continuum of their illness.
4/9/2023 11:44:03 PM +00:00
Long-term survival among colorectal cancer patients in Finland, 1991–2015: A nationwide population-based registry study
Colorectal cancer (CRC) incidence in Finland has risen steadily. Given development in cancer treatments in recent decades, disease-specific data on the long-term prognosis of patients may be obsolete.
4/9/2023 11:43:55 PM +00:00
Safety and efficacy of cabozantinib for patients with advanced hepatocellular carcinoma who advanced to Child–Pugh B liver function at study week 8: A retrospective analysis of the CELESTIAL randomised controlled trial
Patients with hepatocellular carcinoma (HCC) and Child–Pugh B liver cirrhosis have poor prognosis and are underrepresented in clinical trials. The CELESTIAL trial, in which cabozantinib improved overall survival (OS) and progression-free survival (PFS) versus placebo in patients with HCC and Child–Pugh A liver cirrhosis at baseline, was evaluated for outcomes in patients who had Child–Pugh B cirrhosis at Week 8.
4/9/2023 11:43:48 PM +00:00
Observation of the cervical microbiome in the progression of cervical intraepithelial neoplasia
Cervical microbial community in the cervical intraepithelial neoplasia and cervical cancer patients was analysed to study its composition, diversity and signalling pathways by high-throughput 16S rDNA sequencing.
4/9/2023 11:43:41 PM +00:00
Transcriptome analysis reveals the prognostic and immune infiltration characteristics of glycolysis and hypoxia in head and neck squamous cell carcinoma
This study aims to construct a new prognostic gene signature in survival prediction and risk stratification for patients with Head and neck squamous cell carcinoma (HNSCC). The transcriptome profiling data and hallmark gene sets in the Molecular Signatures Database was used to explore the cancer hallmarks most relevant to the prognosis of HNSCC patients.
4/9/2023 11:43:32 PM +00:00
B4GALT5 high expression associated with poor prognosis of hepatocellular carcinoma
B4GALT5 is postulated to be an important protein in sugar metabolism that catalyzes the synthesis of lactosylceramide (LacCer). However, its role in hepatocellular carcinoma (HCC) remains unknown.
4/9/2023 11:43:26 PM +00:00
Genetic and RNA-related molecular markers of trastuzumab-chemotherapy-associated cardiotoxicity in HER2 positive breast cancer: A systematic review
Cancer-therapy-related cardiotoxicity (CTRCT) is a significant and frequent complication of monoclonal antibody-directed therapy, especially Trastuzumab, for human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers. Reliable, clinically available molecular predictive markers of CTRCT have not yet been developed.
4/9/2023 11:43:19 PM +00:00
Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer
Recently it has been recognized that stromal markers could be used as a clinically relevant biomarker for therapy response and prognosis. Here, we report on a serum marker for stromal activation, A Disintegrin and Metalloprotease 12 (ADAM12) in colorectal cancer (CRC).
4/9/2023 11:43:11 PM +00:00
Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs
While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice.
4/9/2023 11:42:58 PM +00:00
Invadopodia play a role in prostate cancer progression
Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation has been observed in-vitro and in-vivo in numerous metastatic cell lines derived from multiple tumour types.
4/9/2023 11:42:51 PM +00:00
A descriptive systematic review of the relationship between personality traits and quality of life of women with non-metastatic breast cancer
Quality of life (QoL) is an important patient-reported outcome that has been studied extensively as an endpoint. There is a growing interest in factors that may influence QoL, such as personality.
4/9/2023 11:42:44 PM +00:00
Synergistic association between underweight and type 2 diabetes on the development of laryngeal cancer: A national population-based retrospective cohort study
Although cigarette smoking is the most significant risk factor for laryngeal cancer, other risk factors might also be associated with the development of laryngeal cancer. We investigated whether underweight and type 2 diabetes are associated with laryngeal cancer in a Korean population.
4/9/2023 11:42:36 PM +00:00
Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer
The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and track patient-specific somatic ctDNA variants, to assess longitudinal changes in disease burden and explore the landscape of actionable alterations.
4/9/2023 11:42:27 PM +00:00
A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: A multicenter retrospective study
Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy.
4/9/2023 11:42:21 PM +00:00