Tài liệu miễn phí Y khoa - Dược
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BIRC5 regulates inflammatory tumor microenvironment-induced aggravation of penile cancer development in vitro and in vivo
Baculoviral IAP repeat containing 5 (BIRC5) is overexpressed and plays as a key regulator in the progression of various human carcinomas. The inflammatory tumor microenvironment (ITM) is closely associated with the development of cancers.
4/9/2023 11:33:28 PM +00:00
Predictive biomarkers for the efficacy of nivolumab as≥ 3rd-line therapy in patients with advanced gastric cancer: A subset analysis of ATTRACTION-2 phase III trial
The phase 3 ATTRACTION-2 study demonstrated that nivolumab monotherapy improved survival compared to placebo in patients with pretreated advanced gastric cancer (AGC). However, the efficacy of nivolumab seems to be limited to a subset of patients.
4/9/2023 11:33:16 PM +00:00
Molecular signatures of tumor progression in pancreatic adenocarcinoma identified by energy metabolism characteristics
In this study, we performed a molecular evaluation of primary pancreatic adenocarcinoma (PAAD) based on the comprehensive analysis of energy metabolism-related gene (EMRG) expression profiles.
4/9/2023 11:33:07 PM +00:00
The oncological safety of autologous fat grafting: A systematic review and meta-analysis
To present a systematic review of the literature and a meta-analysis evaluating the oncological safety of autologous fat grafting (AFG). Summary background data: AFG for breast reconstruction presents difficulties during follow-up radiological exams, and the oncological potential of grafted fat is uncertain.
4/9/2023 11:32:55 PM +00:00
CA19-9 in combination with P-CRP as a predictive marker of immune-related adverse events in patients with recurrent or unresectable advanced gastric cancer treated with nivolumab
Immune-check point inhibitors (ICPIs) for treatment of cancer patients sometimes induce potentially life-threatening immune-related adverse events (irAEs), which predict ICPIs treatment efficacy. Prediction of irAEs would be useful for management of irAEs and prediction of ICPIs efficacy.
4/9/2023 11:32:47 PM +00:00
DNA methylation of miR-138 regulates cell proliferation and EMT in cervical cancer by targeting EZH2
Emerging evidence has identified miR-138 as a tumor suppressor that can suppress the proliferation of various cancers. Meanwhile, the cause of abnormal miR-138 expression in cervical cancer remains uncertain. This study clarified the mechanism by which miR-138 regulates proliferation, invasion, metastasis, and EMT in cervical cancer cells.
4/9/2023 11:32:38 PM +00:00
Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study
Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT1) and ACAT1-mediated cholesterol esterified with fatty acids (CE) contribute to cancer progression in various cancers. Our findings of increased CE and ACAT1 levels in epithelial ovarian cancer (EOC) cell lines prompted us to investigate whether such an increase occurs in primary clinical samples obtained from human subjects diagnosed with EOC.
4/9/2023 11:32:28 PM +00:00
Diagnostic value of circulating genetically abnormal cells to support computed tomography for benign and malignant pulmonary nodules
The accuracy of CT and tumour markers in screening lung cancer needs to be improved. Computeraided diagnosis has been reported to effectively improve the diagnostic accuracy of imaging data, and recent studies have shown that circulating genetically abnormal cell (CAC) has the potential to become a novel marker of lung cancer.
4/9/2023 11:32:21 PM +00:00
The effect of mannitol addition to hydration on acute kidney injury event after high dose cisplatin chemotherapy: An ambispective cohort study
Saline hydration with addition of mannitol have commonly been the strategy to avoid cisplatin induced acute kidney injury (AKI). While the initial reports demonstrated that mannitol diuresis decreased cisplatin induced renal injury, others have shown renal injury to be worsened.
4/9/2023 11:32:14 PM +00:00
Bevacizumab versus PARP-inhibitors in women with newly diagnosed ovarian cancer: A network meta-analysis
In women with newly diagnosed ovarian cancer, bevacizumab and poly (ADP-ribose) polymerase inhibitors (PARPi) exhibit improved progression-free survival (PFS) when administered concurrent with chemotherapy and/or maintenance therapy, but no study has directly compared their effects.
4/9/2023 11:32:08 PM +00:00
Recurrence and prognosis in intrahepatic cholangiocarcinoma patients with different etiology after radical resection: A multi-institutional study
We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection. The prognosis of Stone-ICC patients was significantly worse than those of Con-ICC and HBV-ICC patients. Interestingly, postoperative adjuvant chemotherapy can improve the prognosis of Stone-ICC patients effectively.
4/9/2023 11:32:00 PM +00:00
Clinicopathological features of HER2 positive metastatic colorectal cancer and survival analysis of anti-HER2 treatment
We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effects on patients who received different therapy regimens (including chemotherapy and chemotherapy combined with targeted drugs).
4/9/2023 11:31:53 PM +00:00
Skeletal muscle loss during neoadjuvant chemotherapy predicts poor prognosis in patients with breast cancer
The skeletal muscle index (SMI), which is calculated as the ratio of skeletal muscle area at the third lumbar vertebral level divided by height squared, has been considered a prognostic factor in patients with breast cancer.
4/9/2023 11:31:42 PM +00:00
Pre-diagnostic faecal calprotectin levels in patients with colorectal cancer: A retrospective study
Faecal calprotectin (FC) is a potential biomarker for colorectal cancer (CRC) screening. There is uncertainty if tumor characteristics are associated with FC levels. We investigated how tumor stage and tumor localization influence the extent of FC levels in patients with CRC in clinical practice.
4/9/2023 11:31:31 PM +00:00
Utility of prognostic nutritional index and systemic immune-inflammation index in oral cancer treatment
This study aimed to evaluate the utility of inflammation-based prognostic scores (IBPS) and systemic immune-inflammation index (SII) in the treatment of oral cancer patients.
4/9/2023 11:31:24 PM +00:00
Circulating lymphocyte subsets are prognostic factors in patients with nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a geographically and racially variable disease that has a high incidence in Southeast China. According to previous studies on tumor immunity, we compared multiple clinical parameters and blood indexes with outcomes regarding to Epstein-Barr virus (EBV) status in NPC patients.
4/9/2023 11:31:17 PM +00:00
The impact of neurological performance and volumetrics on overall survival in brain metastasis in colorectal cancer: A retrospective single-center case series
Brain metastasis (BM) of colorectal cancer is a disease with a poor prognosis of only a few months survival. However, it is difficult to estimate the individual prognosis of each patient due to the lack of definitive prognosis parameters.
4/9/2023 11:31:10 PM +00:00
Lack of tumorigenesis and protumorigenic activity of human umbilical cord mesenchymal stem cells in NOD SCID mice
The tumorigenesis of infused umbilical cord mesenchymal stem cells (UC-MSCs) is being preclinically evaluated. Injected hUC-MSCs were not tumorigenic and did not significantly promote or inhibit solid or hemato‑ logical tumor growth or metastasis in NOD SCID mice.
4/9/2023 11:31:03 PM +00:00
Safety and efficacy study of laparoscopic or robotic radical surgery using an endoscopic stapler for inhibiting tumour spillage of cervical malignant neoplasms evaluating survival (SOLUTION): A multi-centre, open-label, single-arm, phase II trial protocol
The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, and End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior to abdominal radical hysterectomy in terms of disease recurrence and survival.
4/9/2023 11:30:55 PM +00:00
N-glycolylneuraminic acid serum biomarker levels are elevated in breast cancer patients at all stages of disease
Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secretions and have been proposed as a cancer biomarker.
4/9/2023 11:30:44 PM +00:00
Serum untargeted lipidomics by UHPLC-ESI-HRMS aids the biomarker discovery of colorectal adenoma
Colorectal adenoma (CA) is an important precancerous lesion and early screening target of colorectal cancer (CRC). Lipids with numerous physiological functions are proved to be involved in the development of CRC. However, there is no lipidomic study with large-scale serum samples on diagnostic biomarkers for CA.
4/9/2023 11:30:36 PM +00:00
Analysis of lncRNA sequences: FAM3D‑AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer
The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is still undetermined.
4/9/2023 11:30:28 PM +00:00
Development and validation of polygenic risk scores for prediction of breast cancer and breast cancer subtypes in Chinese women
Studies investigating breast cancer polygenic risk score (PRS) in Chinese women are scarce. The objectives of this study were to develop and validate PRSs that could be used to stratify risk for overall and subtype-specific breast cancer in Chinese women, and to evaluate the performance of a newly proposed Artificial Neural Network (ANN) based approach for PRS construction.
4/9/2023 11:30:20 PM +00:00
Suppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway
Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy. α-mangostin (αM) has been confirmed to have antiproliferative and apoptotic effects on cancer cells.
4/9/2023 11:30:13 PM +00:00
Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: A prospective and single arm study (DANCE study)
Dacomitinib is a second-generation, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). ARCHER-1050 showed that this agent can improve progression-free survival and overall survival in advanced non-small cell lung cancer patients with sensitive EGFR mutation compared to gefitinib.
4/9/2023 11:30:07 PM +00:00
Rising incidence of HPV positive oropharyngeal cancer in Taiwan between 1999 and 2014 where betel nut chewing is common
The incidence of human papillomavirus (HPV) positive oropharyngeal cancer (OPC) is rising but HPV negative OPC is decreasing in Western countries. In Taiwan, the incidence of HPV negative OPC is common but the incidence of HPV positive OPC remains unknown.
4/9/2023 11:30:00 PM +00:00
Clinical significance of Osaka prognostic score based on nutritional and inflammatory status in patients with esophageal squamous cell carcinoma
t has been reported that Osaka prognostic score (OPS), based on C-reactive protein (CRP), total lymphocyte counts (TLC) and albumin (ALB), was relevant to prognosis in colorectal cancer.
4/9/2023 11:29:53 PM +00:00
Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways
Hepatocellular carcinoma (HCC) is one of the most common clinical malignancies quite susceptible to recurrence and metastasis. Despite several improvements in therapeutic approaches, the prognosis remains poor due to the limited treatment options.
4/9/2023 11:29:43 PM +00:00
Clinical and economic impact of ‘ROS1- testing’ strategy compared to a ‘no-ROS1-testing’ strategy in advanced NSCLC in Spain
Detection of the ROS1 rearrangement is mandatory in patients with advanced or metastatic non-small cell lung cancer (NSCLC) to allow targeted therapy with specific inhibitors. However, in Spanish clinical practice ROS1 determination is not yet fully widespread.
4/9/2023 11:29:36 PM +00:00
Log odds of positive lymph nodes as a novel prognostic predictor for colorectal cancer: A systematic review and meta-analysis
Colorectal cancer (CRC) is the third most prevalent cancer in the world, which remains one of the leading causes of cancer-related deaths. Accurate prognosis prediction of CRC is pivotal to reduce the mortality and disease burden.
4/9/2023 11:29:29 PM +00:00