Tài liệu miễn phí Y khoa - Dược
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Elevated expression of RAB3B plays important roles in chemoresistance and metastatic potential of hepatoma cells
Cancer stem cells (CSCs) are thought to play important roles in carcinogenesis, recurrence, metastasis, and therapy-resistance. We have successfully induced cancer stem-like sphere cells (CSLCs) which possess enhanced chemoresistance and metastatic potential.
4/10/2023 12:07:15 AM +00:00
Serum exosomal proteomics analysis of lung adenocarcinoma to discover new tumor markers
Among the most aggressive and rapidly lethal types of lung cancer, lung adenocarcinoma is the most common type. Exosomes, as a hot area, play an influential role in cancer. By using proteomics analysis, we aimed to identify potential markers of lung adenocarcinoma in serum.
4/10/2023 12:07:07 AM +00:00
Peri-tumoural spatial distribution of lipid composition and tubule formation in breast cancer
Response guided treatment in breast cancer is highly desirable, but the effectiveness is only estab‑ lished based on residual cellularity from histopathological analysis after surgery. Tubule formation, a key component of grading score, is directly associated with cellularity, with significant implications on prognosis.
4/10/2023 12:06:59 AM +00:00
LncRNA CALML3-AS1 suppresses papillary thyroid cancer progression via sponging miR20a-5p/RBM38 axis
The incidence and mortality of thyroid cancer (TC) has been steadily rising in the past decades. It is imperative to have a better understanding of the molecular mechanisms underlying TC development and identify novel therapeutic targets.
4/10/2023 12:06:51 AM +00:00
A pilot study of game-based learning programs for childhood cancer survivors
Childhood cancer survivors lacking awareness on their potential risks of late effects often fail to seek adequate follow-up care. Patient education matching their preference is of great importance to improve their adherence to survivorship care.
4/10/2023 12:06:41 AM +00:00
Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: A systematic review
Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique remain the gold standard for the evaluation of LN metastases despite some limitations, especially low sensitivity in detecting an accurate tumour burden within the LN, as well as a subjective and time-consuming result.
4/10/2023 12:06:31 AM +00:00
Development and validation of a gradient boosting machine to predict prognosis after liver resection for intrahepatic cholangiocarcinoma
Accurate prognosis assessment is essential for surgically resected intrahepatic cholangiocarcinoma (ICC) while published prognostic tools are limited by modest performance. We therefore aimed to establish a novel model to predict survival in resected ICC based on readily-available clinical parameters using machine learning technique.
4/10/2023 12:06:22 AM +00:00
Pedigree investigation, clinical characteristics, and prognosis analysis of haematological disease patients with germline TET2 mutation
Increasing germline gene mutations have been discovered in haematological malignancies with the development of next-generation sequencing (NGS), which is critical for proper clinical management and long-term follow-up of affected individuals.
4/10/2023 12:06:15 AM +00:00
An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy
Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signalling. However, the promise of targeted therapeutic inhibitors, has been tempered by disappointing clinical activity, likely due to complex resistance mechanisms that are not well understood.
4/10/2023 12:06:01 AM +00:00
Exposure–response analyses of cabozantinib in patients with metastatic renal cell cancer
In the registration trial, cabozantinib exposure≥750 ng/mL correlated to improved tumor size reduction, response rate and progression free survival (PFS) in patients with metastatic renal cell cancer (mRCC).
4/10/2023 12:05:54 AM +00:00
Combining gene expression analysis of gastric cancer cell lines and tumor specimens to identify biomarkers for anti-HER therapies— the role of HAS2, SHB and HBEGF
The standard treatment for patients with advanced HER2-positive gastric cancer is a combination of the antibody trastuzumab and platin-fluoropyrimidine chemotherapy. As some patients do not respond to trastuzumab therapy or develop resistance during treatment, the search for alternative treatment options and biomarkers to predict therapy response is the focus of research.
4/10/2023 12:05:47 AM +00:00
New method for determining breast cancer recurrence-free survival using routinely collected real-world health data
In cancer survival analyses using population-based data, researchers face the challenge of ascertaining the timing of recurrence. We previously developed algorithms to identify recurrence of breast cancer. This is a followup study to detect the timing of recurrence.
4/10/2023 12:05:39 AM +00:00
The efficacy and safety of Iodine-131- metaiodobenzylguanidine therapy in patients with neuroblastoma: A meta-analysis
Neuroblastoma is a common extracranial solid tumor of childhood. Recently, multiple treatments have been practiced including Iodine-131-metaiodobenzylguanidine radiation (131I-MIBG) therapy. However, the outcomes of efficacy and safety vary greatly among different studies.
4/10/2023 12:05:29 AM +00:00
Prognostic value and immune relevancy of a combined autophagy-, apoptosisand necrosis-related gene signature in glioblastoma
Glioblastoma (GBM) is considered the most malignant and devastating intracranial tumor without effective treatment. Autophagy, apoptosis, and necrosis, three classically known cell death pathways, can provide novel clinical and immunological insights, which may assist in designing personalized therapeutics.
4/10/2023 12:05:20 AM +00:00
Different inflammatory blood markers correlate with specific outcomes in incident HPV‑negative head and neck squamous cell carcinoma: A retrospective cohort study
Inflammatory blood markers have been associated with oncological outcomes in several cancers, but evidence for head and neck squamous cell carcinoma (HNSCC) is scanty. Therefore, this study aims at investigating the association between five different inflammatory blood markers and several oncological outcomes.
4/10/2023 12:05:09 AM +00:00
Circ_0064288 acts as an oncogene of hepatocellular carcinoma cells by inhibiting miR-335-5p expression and promoting ROCK1 expression
Reportedly, circular RNA (circRNA) is a key modulator in the development of human malignancies. This work is aimed to probe the expression pattern, biological effects and mechanism of circ_0064288 on hepatocellular carcinoma (HCC) progression.
4/10/2023 12:05:01 AM +00:00
A novel nine-microRNA-based model to improve prognosis prediction of renal cell carcinoma
With the improved knowledge of disease biology and the introduction of immune checkpoints, there has been significant progress in treating renal cell carcinoma (RCC) patients. Individual treatment will differ according to risk stratification.
4/10/2023 12:04:49 AM +00:00
Primary versus postoperative gamma knife radiosurgery for intracranial benign meningiomas: A matched cohort retrospective study
The aims of this study were to investigate the long-term outcomes of primary versus postoperative Gamma Knife radiosurgery (GKRS) for benign meningiomas. Methods: Three hundred and forty meningioma patients underwent GKRS were retrospectively reviewed. Patients in the postoperative GKRS group were matched to those in the primary GKRS group, in a 1:1 ratio.
4/10/2023 12:04:39 AM +00:00
Urinary metabolomics for discovering metabolic biomarkers of bladder cancer by UPLC-MS
Bladder cancer (BC) is one of the most frequent cancer in the world, and its incidence is rising worldwide, especially in developed countries. Urine metabolomics is a powerful approach to discover potential biomarkers for cancer diagnosis.
4/10/2023 12:04:32 AM +00:00
Recurrent brain metastases: The role of resection of in a comprehensive multidisciplinary treatment setting
Treatment decision for recurrent symptomatic brain metastases (BM) is challenging with scarce data regarding surgical resection. We therefore evaluated the efficacy of surgery for pretreated, recurrent BM in a compre‑ hensive multidisciplinary treatment setting
4/10/2023 12:04:20 AM +00:00
Anti-tumor treatment and healthcare consumption near death in the era of novel treatment options for patients with melanoma brain metastases
Effective systemic treatments have revolutionized the management of patients with metastatic melanoma, including those with brain metastases. The extent to which these treatments influence disease trajectories close to death is unknown.
4/10/2023 12:04:07 AM +00:00
Primary central nervous system lymphoma high incidence and poor survival in Finnish population-based analysis
We report here the first population-based incidence rates and prognosis of primary central nervous system lymphoma (PCNSL) in Finland. Methods: Finnish Cancer Registry data by histological diagnosis and tumor location (2007–2017) for cases with diffuse large B-cell lymphoma.
4/10/2023 12:04:00 AM +00:00
Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears
Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major cause of death. Despite lower death rates reported from clinical trials, patient registry data suggest an early death rate of 20%, especially for elderly and frail patients.
4/10/2023 12:03:52 AM +00:00
Compliance with recommended cancer patient pathway timeframes and choice of treatment differed by cancer type and place of residence among cancer patients in Norway in 2015–2016
Cancer patient pathways (CPPs) were implemented in Norway to reduce unnecessary waiting times, regional variations, and to increase the predictability of cancer care for the patients. This study aimed to determine if 70% of cancer patients started treatment within the recommended time frames, and to identify potential delays.
4/10/2023 12:03:45 AM +00:00
Long-term outcomes following 90Y Radioembolization of neuroendocrine liver metastases: Evaluation of the radiation-emitting SIR-spheres in non-resectable liver tumor (RESiN) registry
The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry. Toxicities were reported using Common Terminology Criteria for Adverse Events v.5. Cox Proportional Hazards were calculated for pancreatic primary, performance status, extrahepatic disease at treatment, unilobar treatment, baseline ascites, and>25% tumor burden.
4/10/2023 12:03:37 AM +00:00
A 10-year retrospective study of lung cancer in Uganda
Lung cancer is a leading cause of cancer-related deaths in Uganda. In this study, we aimed to describe the baseline characteristics and survival of patients with lung cancer at the Uganda Cancer Institute (UCI).
4/10/2023 12:03:30 AM +00:00
Preoperative versus postoperative chemoradiotherapy for locally advanced gastric cancer: A multicenter propensity score-matched analysis
Peri-operative chemo-radiotherapyplayed important rolein locally advanced gastric cancer. Whether preoperative strategy can improve the long-term prognosis compared with postoperative treatment is unclear.
4/10/2023 12:03:19 AM +00:00
Developing a 5-gene prognostic signature for cervical cancer by integrating mRNA and copy number variations
Cervical cancer is frequently detected gynecological cancer all over the world. This study was designed to develop a prognostic signature for an effective prediction of cervical cancer prognosis.
4/10/2023 12:03:11 AM +00:00
An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The aim of the study is to systematically characterize the lncRNA-associated competing endogenous RNA (ceRNA) network and identify key lncRNAs in the development of stage I lung adenocarcinoma (LUAD).
4/10/2023 12:02:58 AM +00:00
Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma
Annexin A10 expression influences the prognosis of several gastrointestinal cancers. We explored the association of annexin A10 expression with the overall survival (OS) of patients who underwent curative surgery for cholangiocarcinoma.
4/10/2023 12:02:47 AM +00:00