Tài liệu miễn phí Y khoa - Dược
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Pioglitazone and breast cancer risk in female patients with type 2 diabetes mellitus: A retrospective cohort analysis
Whether pioglitazone may affect breast cancer risk in female diabetes patients is not conclusive and has not been investigated in the Asian populations. This study suggests a null association between pioglitazone and breast cancer risk in female patients with type 2 diabetes mellitus.
4/9/2023 11:37:41 PM +00:00
Identification of spatio-temporal clusters of lung cancer cases in Pennsylvania, USA: 2010–2017
It is known that geographic location plays a role in developing lung cancer. The objectives of this study were to examine spatio-temporal patterns of lung cancer incidence in Pennsylvania, to identify geographic clusters of high incidence, and to compare demographic characteristics and general physical and mental health characteristics in those areas.
4/9/2023 11:37:34 PM +00:00
Is lobectomy superior to sub-lobectomy in non-small cell lung cancer with pleural invasion? A population-based competing risk analysis
Pleural invasion (PL) has been regarded as an unfavourable prognostic factor for non-small cell lung cancer (NSCLC). But there was no agreement on the optimal surgical extent in NSCLC patients with PL. We aimed to compare the survival outcomes of lobectomy and sub-lobectomy in these patients.
4/9/2023 11:37:23 PM +00:00
RUNX1 is a promising prognostic biomarker and related to immune infiltrates of cancer-associated fibroblasts in human cancers
Runt-related transcription factor 1 (RUNX1) is a vital regulator of mammalian expression. Despite multiple pieces of evidence indicating that dysregulation of RUNX1 is a common phenomenon in human cancers, there is no evidence from pan-cancer analysis.
4/9/2023 11:37:11 PM +00:00
Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): A phase II study (GASPAR)
Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population.
4/9/2023 11:37:04 PM +00:00
Circulating lnc-LOC as a novel noninvasive biomarker in the treatment surveillance of acute promyelocytic leukaemia
Acute promyelocytic leukaemia (APL) is a unique subtype of acute myeloid leukaemia (AML) characterized by haematopoietic failure caused by the accumulation of abnormal promyelocytic cells in bone marrow (BM).
4/9/2023 11:36:56 PM +00:00
Gestational trophoblastic neoplasia with extrauterine metastasis but lacked uterine primary lesions: A single center experience and literature review
To investigate the clinicopathological characteristics, diagnoses, treatments, and outcomes of a special type of gestational trophoblastic neoplasia (GTN) which only has extrauterine metastases without uterine primary lesions.
4/9/2023 11:36:48 PM +00:00
Long-term outcome and relapse patterns in Ewing sarcoma patients with extensive lung/ pleural metastases after a complete response to systemic therapy
Ewing sarcoma (ES) is sensitive to systemic therapy, including chemotherapy and anti-angiogenesis Tyrosine Kinase Inhibitors(aaTKIs). However, the prognosis of patients with metastatic disease remains poor. Recurrence or distant metastasis after a complete response (CR) or near-CR due to systemic therapy is not rare.
4/9/2023 11:36:41 PM +00:00
Postoperative radiotherapy for meningiomas – a decision-making analysis
The management of meningiomas is challenging, and the role of postoperative radiotherapy is not standardized. Methods: Radiation oncology experts in Swiss centres were asked to participate in this decision-making analysis on the use of postoperative radiotherapy (RT) for meningiomas.
4/9/2023 11:36:34 PM +00:00
Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan
Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxifcation of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors.
4/9/2023 11:36:26 PM +00:00
Homologous recombination deficiency in diverse cancer types and its correlation with platinum chemotherapy efficiency in ovarian cancer
Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD is pathogenic BRCA1/2 mutations, while HRD phenotype is also present in patients without BRCA1/2 alterations, suggesting other unknown factors.
4/9/2023 11:36:16 PM +00:00
Prognosis of resected non-small cell lung cancer with pleural plaques on intrathoracic findings
The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteristics and prognosis of these patients to those of patients without pleural plaques.
4/9/2023 11:36:08 PM +00:00
Association of institutional transition of cancer care with mortality in elderly patients with lung cancer: A retrospective cohort study using national claim data
Although survival based outcomes of lung cancer patients have been well developed, institutional transition of cancer care, that is, when patients transfer from primary visiting hospitals to other hospitals, and mortality have not yet been explored using a large-scale representative population-based sample.
4/9/2023 11:36:01 PM +00:00
Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: A multi-centre cohort study
Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored.
4/9/2023 11:35:54 PM +00:00
Identification of immune infiltration-related genes as prognostic indicators for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a high degree of malignancy and a poor prognosis. Immune infiltration-related genes have shown good predictive value in the prognosis of many solid tumours. In this study, we established and verified prognostic biomarkers consisting of immune infiltration-related genes in HCC.
4/9/2023 11:35:46 PM +00:00
Burden of cancers in India - estimates of cancer crude incidence, YLLs, YLDs and DALYs for 2021 and 2025 based on National Cancer Registry Program
Cancer is the major cause of morbidity and mortality worldwide. The cancer burden varies within the regions of India posing great challenges in its prevention and control. The national burden assessment remains as a task which relies on statistical models in many developing countries, including India, due to cancer not being a notifiable disease.
4/9/2023 11:35:38 PM +00:00
The identification of liver metastasisand prognosis-associated genes in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an often fatal malignancy with an extremely low survival rate. Liver metastasis, which causes high mortality, is the most common recurring metastasis for PDAC. However, the mechanisms underlying this liver metastasis and associated candidate biomarkers are unknown.
4/9/2023 11:35:29 PM +00:00
Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/ L1CAM/NF-κB signalling pathway
Glioma is one of the main causes of cancer-related mortality worldwide and is associated with high heterogeneity. However, the key players determining the fate of glioma remain obscure. In the present study, we shed light on tumor metabolism and aimed to investigate the role of tryptophan hydroxylase 1 (TPH-1) in the advancement of glioma.
4/9/2023 11:35:21 PM +00:00
Image-guided navigation for locally advanced primary and locally recurrent rectal cancer: Evaluation of its early cost-effectiveness
A first pilot study showed that an image-guided navigation system could improve resection margin rates in locally advanced (LARC) and locally recurrent rectal cancer (LRRC) patients. Incremental surgical innovation is often implemented without reimbursement consequences, health economic aspects should however also be taken into account.
4/9/2023 11:35:14 PM +00:00
Utilization of radiation therapy and predictors of noncompliance among Syrian refugees in Turkey
Access to cancer care is a problem that continues to plague refugees displaced from their home countries. The turbulent political crisis in Syria, which has led to millions of refugees seeking asylum in Turkey, merits further attention.
4/9/2023 11:35:07 PM +00:00
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway
The Lauren classification of gastric tumors strongly correlates with prognosis. The purpose of this study was to explore the specific molecular mechanism of Lauren classification of gastric cancer and provide a possible theoretical basis for the treatment of gastric cancer.
4/9/2023 11:34:56 PM +00:00
Exploration of mRNAs and miRNA classifiers for various ATLL cancer subtypes using machine learning
Adult T-cell Leukemia/Lymphoma (ATLL) is a cancer disease that is developed due to the infection by human T-cell leukemia virus type 1. It can be classified into four main subtypes including, acute, chronic, smoldering, and lymphoma.
4/9/2023 11:34:49 PM +00:00
Association between effector-type regulatory T cells and immune checkpoint expression on CD8+ T cells in malignant ascites from epithelial ovarian cancer
Regulatory T cells (Tregs) play an important role in the antitumor immune response in epithelial ovarian cancer (EOC). To understand the immune-inhibitory networks of EOC, we addressed the association between Tregs and immune checkpoint expression on T cells in the tumor microenvironment of EOC.
4/9/2023 11:34:41 PM +00:00
Association of histological features with laryngeal squamous cell carcinoma recurrences: A population-based study of 1502 patients in the Netherlands
Recurrences remain an important problem in laryngeal squamous cell carcinoma. Little has been described about histological characteristics of the primary laryngeal tumor that may be associated with recurrences. Identifying risk factors for recurrences might help in adapting treatment or follow-up.
4/9/2023 11:34:33 PM +00:00
Identification of a pyroptosis-related prognostic signature in breast cancer
The relationship between pyroptosis and cancer is complex. It is controversial that whether pyroptosis represses or promotes tumor development. This study aimed to explore prognostic molecular characteristics to predict the prognosis of breast cancer (BRCA) based on a comprehensive analysis of pyroptosis-related gene expression data.
4/9/2023 11:34:23 PM +00:00
CT-707 overcomes hypoxia-mediated sorafenib resistance in Hepatocellular carcinoma by inhibiting YAP signalling
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indicated by its low response rates and failure to prolong the progression-free survival (PFS).
4/9/2023 11:34:16 PM +00:00
Machine learning-based multiparametric MRI radiomics for predicting poor responders after neoadjuvant chemoradiotherapy in rectal Cancer patients
The purpose of this study was to investigate and validate multiparametric magnetic resonance imaging (MRI)-based machine learning classifiers for early identification of poor responders after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC).
4/9/2023 11:34:08 PM +00:00
Combined chemoradiotherapy showed improved outcome with early-stage HPV-positive oropharyngeal cancers
The revised 8th Edition American Joint Committee on Cancer (AJCC) Head and Neck Staging Manual distinguishes HPV-mediated from non-HPV-mediated oropharyngeal cancer (OpSCC). The objective was to analyze OpSCC treatment modalities and outcomes.
4/9/2023 11:34:01 PM +00:00
Autophagy modulating therapeutics inhibit ovarian cancer colony generation by polyploid giant cancer cells (PGCCs)
Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: That of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher than diploid chromosome content.
4/9/2023 11:33:48 PM +00:00
Vegetable and fruit consumption and cancer of unknown primary risk: Results from the Netherlands cohort study on diet and cancer
Cancer of Unknown Primary (CUP) is a metastatic cancer for which the primary lesion remains unidentifiable during life and little is also known about the modifiable risk factors that contribute to its development. This study investigates whether vegetables and fruits are associated with CUP risk.
4/9/2023 11:33:41 PM +00:00