Tài liệu miễn phí Y khoa

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Tài liệu miễn phí Y khoa - Dược

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Octogenarian patients with colon cancer – postoperative morbidity and mortality are the major challenges

Few studies have addressed colon cancer surgery outcomes in an unselected cohort of octogenarian patients. The present study aimed to evaluate the relative survival of octogenarian patients after a major resection of colon cancer with a curative intent.

4/9/2023 11:29:17 PM +00:00

Osteoclasts differential-related prognostic biomarker for osteosarcoma based on single cell, bulk cell and gene expression datasets

Osteosarcoma (OS) is one of the most common primary bone malignant tumors. Osteoclasts have been shown to have a valuable role in OS. In the present study, we analyzed the differentiation states of osteoclasts in OS and their prognostic significance based on integrated scRNA-seq and bulk RNA-seq data.

4/9/2023 11:29:07 PM +00:00

Expression of the preadipocyte marker ZFP423 is dysregulated between well differentiated and dedifferentiated liposarcoma

Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential.

4/9/2023 11:28:58 PM +00:00

PARP inhibitors chemopotentiate and synergize with cisplatin to inhibit bladder cancer cell survival and tumor growth

Management of bladder cancer (BLCA) has not changed significantly in the past few decades, with platinum agent chemotherapy being used in most cases. Chemotherapy reduces tumor recurrence after resection, but debilitating toxicities render a large percentage of patients ineligible.

4/9/2023 11:28:49 PM +00:00

Understanding breast cancer risk factors: Is there any mismatch between laywomen perceptions and expert opinions

Women’s perception and knowledge of breast cancer signs, symptoms, and risk factors could be conducive to breast cancer risk management and interventions. The present study aimed to explore Iranian laywomen perceptions and expert opinions regarding breast cancer risk factors.

4/9/2023 11:28:39 PM +00:00

Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

The BIRC5 gene encodes for the Survivin protein, which is a member of the inhibitor of apoptosis family. Survivin is found in humans during fetal development, but generally not in adult cells thereafter

4/9/2023 11:28:32 PM +00:00

Quality and efficacy of Multidisciplinary Team (MDT) quality assessment tools and discussion checklists: A systematic review

MDT discussion is the gold standard for cancer care in the UK. With the incidence of cancer on the rise, demand for MDT discussion is increasing. The need for efficiency, whilst maintaining high standards, is therefore clear.

4/9/2023 11:28:25 PM +00:00

The targeted SMAC mimetic SW IV-134 augments platinum-based chemotherapy in pre-clinical models of ovarian cancer

Ovarian cancer is initially responsive to frontline chemotherapy. Unfortunately, it often recurs and becomes resistant to available therapies and the survival rate for advanced and recurrent ovarian cancer is unacceptably low.

4/9/2023 11:28:18 PM +00:00

Real-world burden of adverse events for apalutamide- or enzalutamide-treated non-metastatic castration-resistant prostate cancer patients in the United States

Second-generation androgen receptor inhibitors (ARIs) have been associated with adverse events (AEs) such as fatigue, falls, fractures, and rash in non-metastatic castration-resistant prostate cancer (nmCRPC) patients as identified in clinical trials.

4/9/2023 11:28:11 PM +00:00

Intraepithelial lymphocytes are indicators of better prognosis in surgically resected endometrioid-type endometrial carcinomas at early and advanced stages

Tumour-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may be useful prog‑ nostic indicators in endometrial cancer. However, standardized assessment methods and the prognostic roles of these cells in different stage groups are unclear.

4/9/2023 11:28:02 PM +00:00

Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

The trend of women suffering from early-onset breast cancer is increasing in Taiwan. The association of early-onset breast cancer with body mass index (BMI), menarche, and menopausal status has focused interest on the field of cancer epidemiology; however, few studies have explored the interaction of these factors on early-onset risk.

4/9/2023 11:27:54 PM +00:00

Context dependent isoform-specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver disease stages and cirrhosis.

4/9/2023 11:27:46 PM +00:00

NAP1L1 promotes tumor proliferation through HDGF/C-JUN signalling in ovarian cancer

Nucleosome assembly protein 1-like 1 (NAP1L1) is highly expressed in various types of cancer and plays an important role in carcinogenesis, but its specific role in tumor development and progression remains largely unknown.

4/9/2023 11:27:38 PM +00:00

Gene signature associated with resistance to fluvastatin chemoprevention for breast cancer

Although targeting of the cholesterol pathway by statins prevents breast cancer development in mouse models, efficacy is not absolute. Therefore, the goal of this study is to investigate if the upregulation in the cholesterol biosynthesis pathway genes associates with response to statin chemoprevention and may potentially be used as response biomarkers.

4/9/2023 11:27:28 PM +00:00

Comparison of tumors with HER2 overexpression versus HER2 amplification in HER2-positive breast cancer patients

Human epidermal growth factor receptor 2 (HER2)-positive tumors are defined by protein overexpression (3+) or gene amplifcation using immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH), respectively.

4/9/2023 11:27:16 PM +00:00

Short-course radiotherapy combined with CAPOX and Toripalimab for the total neoadjuvant therapy of locally advanced rectal cancer: A randomized, prospective, multicentre, double-arm, phase II trial (TORCH)

For patients with locally advanced (T3-4/N+) rectal cancer (LARC), the standard treatment is neoadjuvant chemoradiotherapy combined with total mesorectal resection, which greatly decreases local recurrence but does not improve overall survival.

4/9/2023 11:27:10 PM +00:00

Development of nomogram models of inflammatory markers based on clinical database to predict prognosis for hepatocellular carcinoma after surgical resection

Inflammation plays a significant role in tumour development, progression, and metastasis. In this study, we focused on comparing the predictive potential of inflammatory markers for overall survival (OS), recurrence-free survival (RFS), and 1- and 2-year RFS in hepatocellular carcinoma (HCC) patients.

4/9/2023 11:27:02 PM +00:00

Overview of adjuvant radiotherapy on survival, failure pattern and toxicity in stage I to II endometrial carcinoma: A long-term multiinstitutional analysis in China

This research aimed to provide an overview of the impact of adjuvant vaginal brachytherapy (VBT) and external beam pelvic radiotherapy (EBRT) with or without VBT on survival in stage I to II EC patients in China from a long-term multi-institutional analysis.

4/9/2023 11:26:55 PM +00:00

Trends in treatment patterns and survival outcomes in advanced non-small cell lung cancer: A Canadian population-based real-world analysis

As part of the multi-country I-O Optimise research initiative, this population-based study evaluated real-world treatment patterns and overall survival (OS) in patients treated for advanced non-small cell lung cancer (NSCLC) before and after public reimbursement of immuno-oncology (I-O) therapies in Alberta province, Canada.

4/9/2023 11:26:47 PM +00:00

The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients

Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adenocarcinomas; however, its importance in GC remains undetermined.

4/9/2023 11:26:40 PM +00:00

Incidence and survival in oral and pharyngeal cancers in Finland and Sweden through half century

Cancers of the oral cavity and pharynx encompass a heterogeneous group of cancers for which known risk factors include smoking, alcohol consumption and human papilloma virus (HPV) infection but their influence is site-specific with HPV mainly influencing oropharyngeal cancer.

4/9/2023 11:26:30 PM +00:00

Feasibility of a fast-track randomized controlled trial of cell-free and concentrated ascites reinfusion therapy for patients with refractory malignant ascites

Malignant ascites often causes discomfort in advanced cancer patients. Paracentesis is the most common treatment modality, but it requires frequently repeated treatment. Cell-free and concentrated ascites reinfusion therapy (CART) may prolong the paracentesis interval, but controlled trials are lacking.

4/9/2023 11:26:23 PM +00:00

Assessment of transparency and selective reporting of interventional trials studying colorectal cancer

Colorectal cancer (CRC) is currently one of the most frequently diagnosed cancers. Our aim was to evaluate transparency and selective reporting in interventional trials studying CRC.

4/9/2023 11:26:12 PM +00:00

Biweekly oxaliplatin plus S1 for Chinese elderly patients with advanced gastric or gastroesophageal junction cancer as the first-line therapy: A single-arm, phase 2 study

SOX (oxaliplatin and S1, every 3 weeks) is one of the most common first-line chemotherapy for advanced or metastatic G/GEJ (gastric or gastroesophageal junction) cancer in Asia, but it has noticeable hematological and neurological toxicity.

4/9/2023 11:26:06 PM +00:00

Predicting biochemical-recurrence-free survival using a three-metabolic-gene risk score model in prostate cancer patients

Biochemical recurrence (BCR) after initial treatment, such as radical prostatectomy, is the most frequently adopted prognostic factor for patients who suffer from prostate cancer (PCa). In this study, we aimed to construct a prognostic model consisting of gene expression profiles to predict BCR-free survival.

4/9/2023 11:25:59 PM +00:00

Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1

Glioma cells are characterized by high migration ability, resulting in aggressive growth of the tumors and poor prognosis of patients. It has been reported that the stress-induced hormone norepinephrine (NE) contributes to tumor progression through mediating a number of important biological processes in various cancers.

4/9/2023 11:25:50 PM +00:00

Additional capecitabine use in early-stage triple negative breast cancer patients receiving standard chemotherapy: A new era? A meta-analysis of randomized controlled trials

The efficiency of capecitabine has been proven in early-stage triple negative breast cancer (eTNBC) with residue invasive tumor (non-pCR) after standard neoadjuvant chemotherapy (NACT). However, for those unselected eTNBC patients without screening from NACT (i.e., newly diagnosed eTNBC patients undergoing breast surgery followed by adjuvant systemic therapy), the value of capecitabine has still remains unclear.

4/9/2023 11:25:43 PM +00:00