Tài liệu miễn phí Y khoa - Dược
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Improving health-related quality of life in women with breast, blood, and gynaecological Cancer with an eHealth-enabled 12-week lifestyle intervention: The women’s wellness after Cancer program randomised controlled trial
The residual effects of cancer and its treatment can profoundly affect women’s quality of life. This paper presents results from a multisite randomized controlled trial that evaluated the clinical benefits of an e-health enabled health promotion intervention (the Women’s Wellness after Cancer Program or WWACP) on the health-related quality of life of women recovering from cancer treatment.
4/9/2023 11:54:22 PM +00:00
Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma
The role of the PRDM5 in esophageal squamous cell carcinoma (ESCC) has not been revealed. This study investigated the relationship between PRDM5 expression and survival outcome in esophageal squamous cell carcinoma and explored the mechanism in tumor development.
4/9/2023 11:54:15 PM +00:00
Metabolic activity determines survival depending on the level of lymph node involvement in cervical cancer
To assess the impact of PET/CT functional parameters on survival, locoregional, and distant failure according to the most distant level of lymph node [ 18F]FDG uptake in patients with locally advanced cervical cancer (LACC).
4/9/2023 11:54:03 PM +00:00
A population-based validation study of the 8th edition UICC/AJCC TNM staging system for cutaneous melanoma
The 8th edition UICC/AJCC TNM8 (Tumour, Nodes, Metastasis) melanoma staging system introduced several modifications from the 7th edition (TNM7), resulting in changes in survival and subgroup composition. We set out to address the limited validation of TNM8 (stages I-IV) in large population-based datasets.
4/9/2023 11:53:52 PM +00:00
Targeting autophagy increases the efficacy of proteasome inhibitor treatment in multiple myeloma by induction of apoptosis and activation of JNK
The therapeutic armamentarium in multiple myeloma has been significantly broadened by proteasome inhibitors, highly efficient means in controlling of multiple myeloma. Despite the developments of therapeutic regimen in treatment of multiple myeloma, still the complete remission requires a novel therapeutic strategy with significant differences in outcomes.
4/9/2023 11:53:44 PM +00:00
A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs
During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of significant drug interactions (DIs). This study describes DIs in cancer patients and their prevalence and predictors.
4/9/2023 11:53:36 PM +00:00
Identifying and handling unbalanced baseline characteristics in a non-randomized, controlled, multicenter social care nurse intervention study for patients in advanced stages of cancer
Given the psychosocial burdens patients in advanced stages of cancer face, innovative care concepts are needed. At the same time, such vulnerable patient groups are difficult to reach for participation in intervention studies and randomized patient inclusion may not be feasible.
4/9/2023 11:53:28 PM +00:00
Laminin-integrin a6b4 interaction activates notch signalling to facilitate bladder cancer development
Laminins are high-molecular weight (400~900 kDa) proteins in extracellular matrix, which serve as major component of the basal lamina, and play a crucial role in promoting tumor cell migration. This study aimed at characterizing the role of laminin in promoting cancer development, and elucidating the mechanism of tumor progression driven by laminin-Notch signalling in bladder cancer.
4/9/2023 11:53:20 PM +00:00
Safety and efficacy of pegylated recombinant human granulocyte colony-stimulating factor during concurrent chemoradiotherapy for small-cell lung cancer: A retrospective, cohort-controlled trial
To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing haematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell lung cancer (SCLC).
4/9/2023 11:53:13 PM +00:00
RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma
Accumulated evidence suggests that RING finger proteins (RNFs) are involved in the carcinogenesis of cancers. However, RNF38, a member of the RNF protein family, has not been studied in nasopharyngeal carcinoma (NPC).
4/9/2023 11:53:05 PM +00:00
Impact of geriatric nutritional risk index on outcomes after gastrectomy in elderly patients with gastric cancer: A retrospective multicenter study in Japan
Several studies investigated the utility of inflammation and nutritional markers in predicting the prognosis in patients with gastric cancer; however, the markers with the best predictive ability remain unclear.
4/9/2023 11:52:58 PM +00:00
Association of CTLA‑4 and IL‑4 polymorphisms in viral induced liver cancer
Hepatocellular carcinoma (HCC) is one of the most prevalent types of cancer and is responsible for close to one million annual deaths globally. In Pakistan, HCC accounts for 10.7% of cancer incidence.
4/9/2023 11:52:52 PM +00:00
SCARA3 inhibits cell proliferation and EMT through AKT signalling pathway in lung cancer
Scavenger receptor class A member 3 (SCARA3) is decreased in prostate cancer and myeloma. However, functions of SCARA3 in various cancers remain unclear. In this study, we tried to evaluate the functional study of SCARA3 in lung cancer.
4/9/2023 11:52:44 PM +00:00
Overexpression of angiogenic factors and matrix metalloproteinases in the saliva of oral squamous cell carcinoma patients: Potential non-invasive diagnostic and therapeutic biomarkers
Salivary biomarkers hold huge potential for the non-invasive diagnosis of oral squamous cell carcinoma. Angiogenic factors and matrix-metalloproteinases (MMPs) are highly expressed in OSCC tissue, but their expression patterns in the saliva are unknown. This study aimed to analyze the levels of angiogenic factors and MMPs in tumor tissue and saliva of OSCC patients.
4/9/2023 11:52:35 PM +00:00
Reflecting on the utility of standardized uptake values on 18F-FDG PET in nasopharyngeal carcinoma
To rethink the clinical significance of standardized uptake values (SUVs) of nasopharyngeal carcinoma (NPC) on 18F-fuorodeoxyglucose (18F-FDG) positron-emission tomography (PET).
4/9/2023 11:52:24 PM +00:00
Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer
Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived organoids (PDOs).
4/9/2023 11:52:15 PM +00:00
A novel and sensitive DNA methylation marker for the urine-based liquid biopsies to detect bladder cancer
Better prognostic outcome is closely correlated with early detection of bladder cancer. Current noninvasive urianalysis relies on simultaneously testing multiple methylation markers to achieve relatively high accuracy.
4/9/2023 11:52:09 PM +00:00
High MICAL-L2 expression and its role in the prognosis of colon adenocarcinoma
MICAL-like protein 2 (MICAL-L2), a member of the molecules interacting with CasL (MICAL) family of proteins, is strongly associated with the malignancy of multiple types of cancer. However, the role of MICAL-L2 in colon adenocarcinoma (COAD) has not been well characterized.
4/9/2023 11:52:02 PM +00:00
Cost-effectiveness of using artificial intelligence versus polygenic risk score to guide breast cancer screening
Using artificial Intelligence (AI) to read mammography images has been shown to predict breast cancer risk with higher accuracy than alternative approaches including polygenic risk scores (PRS), raising the question whether AI-based screening is more cost-effective than screening based on PRS or existing guidelines. This study provides the first evidence to shed light on this important question.
4/9/2023 11:51:55 PM +00:00
Stimulating TAM-mediated anti-tumor immunity with mannose-decorated nanoparticles in ovarian cancer
Current cancer immunotherapies have made tremendous impacts but generally lack high response rates, especially in ovarian cancer. New therapies are needed to provide increased benefits. One understudied approach is to target the large population of immunosuppressive tumor-associated macrophages (TAMs).
4/9/2023 11:51:48 PM +00:00
Digital phenotyping in young breast cancer patients treated with neoadjuvant chemotherapy (the NeoFit Trial): Protocol for a national, multicenter single-arm trial
Breast cancer (BC) has particular characteristics in young women, with diagnosis at more advanced stages, a poorer prognosis and highly aggressive tumors. In NeoFit, we will use an activity tracker to identify and describe various digital profiles (heart rate, physical activity, and sleep patterns) in women below the age of 45 years on neoadjuvant chemotherapy for BC.
4/9/2023 11:51:40 PM +00:00
MTHFD2 is a potential oncogene for its strong association with poor prognosis and high level of immune infiltrates in urothelial carcinomas of bladder
The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers.
4/9/2023 11:51:32 PM +00:00
Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain.
4/9/2023 11:51:25 PM +00:00
The relationship between medication literacy and skin adverse reactions in non-small-cell lung cancer patients undergoing targeted EGFR-TKI therapy
High medication literacy is the basis of rational medication application and is essential for the management of severe adverse drug reactions. The objective of the present study was to assess the level of medication literacy and determine the association between medication literacy and skin adverse drug reactions in non-small-cell lung cancer (NSCLC) patients undergoing targeted epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy.
4/9/2023 11:51:17 PM +00:00
Efficacy of first-line treatments in the elderly and non-elderly patients with advanced epidermal growth factor receptor mutated, non-small cell lung cancer: A network meta-analysis
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the current standard of care for advanced or metastatic non-small cell lung cancer (NSCLC) patients harboring EGFR activating mutations.
4/9/2023 11:51:10 PM +00:00
The frequency and clinical implication of mismatch repair protein deficiency in Chinese patients with ovarian clear cell carcinoma
The aim of the present study was to assess the prevalence of deficient mismatch repair (MMR) in Chinese ovarian clear cell carcinoma (CCC) patients and its association with clinicopathologic features.
4/9/2023 11:51:02 PM +00:00
Effects of intensive physiotherapy on Quality of Life (QoL) after pancreatic cancer resection: A randomized controlled trial
Patients have signifcantly lower QoL scores after pancreatic resection due to cancer in the physical and psychological domains compared to healthy controls or other cancer patients. Intensifed physiotherapy or physical training can increase QoL by reducing fatigue levels and improving physical functioning.
4/9/2023 11:50:56 PM +00:00
Increased use of diagnostic CT imaging increases the detection of stage IA lung cancer: Pathways and patient characteristics
At Silkeborg Regional Hospital, Denmark, the number of stage IA lung cancer increased after implementation of increased use of CT investigations and a corresponding reduction in chest X-ray. The aim of the present study was to understand the changes in referral pathways, patient characteristics and imaging procedures behind the observed increase in early-stage lung cancer.
4/9/2023 11:50:49 PM +00:00
Development and validation of a radiomics-based nomogram for the preoperative prediction of microsatellite instability in colorectal cancer
Preoperative prediction of microsatellite instability (MSI) status in colorectal cancer (CRC) patients is of great significance for clinicians to perform further treatment strategies and prognostic evaluation.
4/9/2023 11:50:39 PM +00:00
Cervical, vaginal and vulvar cancer incidence and survival trends in Denmark, Finland, Norway and Sweden with implications to treatment
Incidence of cervical cancer has been reduced by organized screening while for vaginal and vulvar cancers no systematic screening has been implemented. All these cancers are associated with human papilloma virus (HPV) infection.
4/9/2023 11:50:28 PM +00:00