Tài liệu miễn phí Y khoa - Dược
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Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms
Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins.
4/9/2023 11:42:10 PM +00:00
Evolution of patterns of care for women with cervical cancer in Morocco over a decade
We conducted a Pattern-of-care (POC) study at two premier-most public-funded oncology centers in Morocco to evaluate delays in care continuum and adherence to internationally accepted treatment guidelines of cervical cancer.
4/9/2023 11:42:03 PM +00:00
Durvalumab after chemoradiotherapy for locally advanced non-small cell lung cancer prolonged distant metastasis-free survival, progression-free survival and overall survival in clinical practice
In clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is not fully understood. The purpose of this retrospective study was to investigate factors related to distant metastasis-free survival (DMFS), progression-free survival (PFS) and overall survival (OS) after IMRT for locally advanced non-small cell lung cancer (LA-NSCLC).
4/9/2023 11:41:53 PM +00:00
Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: A retrospective chart review
High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment.
4/9/2023 11:41:46 PM +00:00
Single fraction ablative preoperative radiation treatment for early-stage breast cancer: The CRYSTAL study – a phase I/II clinical trial protocol
Breast-conserving surgery (BCS) and whole breast radiation therapy (WBRT) are the standard of care for early-stage breast cancer (BC). Based on the observation that most local recurrences occurred near the tumor bed, accelerated partial breast irradiation (APBI), consisting of a higher dose per fraction to the tumor bed over a reduced treatment time, has been gaining ground as an attractive alternative in selected patients with low-risk BC.
4/9/2023 11:41:39 PM +00:00
RHOA protein expression correlates with clinical features in gastric cancer: A systematic review and meta-analysis
Gastric cancer (GC) is one of the most fatal cancers worldwide and is generally only detected after it has progressed to an advanced stage. Since there is a lack of comprehensive data on RHOA protein expression of patients with GC, this study utilized a systematic review and meta-analysis to address the limitation.
4/9/2023 11:41:33 PM +00:00
Prognostic value of CSN5 in patients with digestive system cancers: A systematic review and meta-analysis
Despite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to predict the survival and prognosis of digestive system tumor patients. Hence this study aimed to evaluate the impact of CSN5 levels on the survival and clinicopathological parameters of digestive system neoplasm patients.
4/9/2023 11:41:24 PM +00:00
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway
T-cell immunoglobulin mucin-1 (TIM-1) has been reported to be associated with the biological behavior of several malignant tumors; however, it is not clear whether it has a role in cervical cancer (CC).
4/9/2023 11:41:11 PM +00:00
Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers
Emerging cell- or tissue-based evidence has demonstrated that opsin 3 (OPN3) mediates a variety of pathological processes affecting tumorigenesis, clinical prognosis, and treatment resistance in some cancers.
4/9/2023 11:41:03 PM +00:00
A potential decision-making algorithm based on endoscopic ultrasound for staging early gastric cancer: A retrospective study
Clinical staging of gastric cancer (GC) before treatment is essential. Endoscopic ultrasound (EUS) is a recommended staging tool, but its efficacy remains controversial. Our previous prospective study evaluated the potential value of EUS for T staging and presented discrepancies.
4/9/2023 11:40:53 PM +00:00
Genomic signature of MTOR could be an immunogenicity marker in human colorectal cancer
The mTOR signalling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects pathway activity and the efficacy of mTOR inhibitor therapy. However, little research has been performed to explore MTOR in colorectal cancer (CRC).
4/9/2023 11:40:42 PM +00:00
TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma
Temozolomide (TMZ) resistance remains the main therapy challenge in patients with glioblastoma multiforme (GBM). TTK Protein Kinase (TTK) contributes to the radioresistance and chemoresistance in many malignancies. However, the role of TTK in the TMZ resistance of GBM cells remains unknown.
4/9/2023 11:40:30 PM +00:00
Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes
The WNT signal pathway has myriad family members, which are broadly involved in embryonic development and human cancer. Over-activation of WNT-β-Catenin signalling promotes cancer cell proliferation and survival.
4/9/2023 11:40:22 PM +00:00
A prospective cohort study on the association between waterpipe tobacco smoking and gastric cancer mortality in Northern Vietnam
Tobacco consumption, as a worldwide problem, is a risk factor for several types of cancer. In Vietnam, tobacco consumption in the form of waterpipe tobacco smoking is common. This prospective cohort study aimed to study the association between waterpipe tobacco smoking and gastric cancer mortality in Northern Vietnam.
4/9/2023 11:40:16 PM +00:00
Neoadjuvant docetaxel, oxaliplatin and S-1 therapy for the patients with large type 3 or type 4 gastric cancer (OGSG1902): Protocol of a multi-center, phase II study
Large type 3 and type 4 gastric cancers have extremely poor prognoses. To address this, neoadjuvant chemotherapy may be a promising approach. The phase III JCOG0501 study, conducted to confirm the superiority of neoadjuvant S-1 plus cisplatin followed by D2 gastrectomy over upfront surgery, showed no survival benefit for neoadjuvant S-1 plus cisplatin.
4/9/2023 11:40:09 PM +00:00
Prognostic value of tumor-infiltrating lymphocytes in DCIS: A meta-analysis
Tumor infiltrating lymphocytes (TILs) have been shown to be associated with the prognosis of breast ductal carcinoma in situ (DCIS). In this systematic review and meta-analysis, we investigated the role of TILs and TIL subsets in predicting the recurrence risk of DCIS.
4/9/2023 11:40:02 PM +00:00
The effect of Orem-based self-care education on improving self-care ability of patients undergoing chemotherapy: A randomized clinical trial
Cancer is a frightening disease. Therefore, the care of cancer patients is very complex. This study aimed to investigate the effect of the education based on Orem’s self-care model on self-care abilities of the patients undergoing chemotherapy in Shafa Hospital in Ahvaz city, Iran.
4/9/2023 11:39:55 PM +00:00
Circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via regulating HSP70 and MAPK pathway
Head and neck squamous cell carcinoma (HNSCC) is one severe malignancy driven by complex cellular and signalling mechanisms. However, the roles of circular RNAs (circRNAs) in HNSCC’s development remains poorly understood.
4/9/2023 11:39:45 PM +00:00
ASIC1α up-regulates MMP-2/9 expression to enhance mobility and proliferation of liver cancer cells via the PI3K/AKT/mTOR pathway
A major challenge in the treatment of liver cancer is that a large proportion of patients fail to achieve long-term disease control, with death from liver cancer cell migration and invasion. Acid-sensitive ion channel 1α (ASIC1α) is involved in the migration, invasion, and proliferation of liver cancer cells.
4/9/2023 11:39:30 PM +00:00
RhG-CSF is associated with an increased risk of metastasis in NSCLC patients following postoperative chemotherapy
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) reduces neutropenia events and is widely used in cancer patients receiving chemotherapy. However, the effects of rhG-CSF on distant organ metastasis (DOM) in non-small-cell lung cancer (NSCLC) patients following postoperative chemotherapy are not clear.
4/9/2023 11:39:22 PM +00:00
Anesthetic propofol enhances cisplatin-sensitivity of non-small cell lung cancer cells through N6-methyladenosine-dependently regulating the miR-486-5p/RAP1-NF-κB axis
Drug resistance is a considerable challenge for chemotherapy in non-small cell lung cancer (NSCLC). Propofol, a commonly used intravenous anesthetics, has been reported to suppress the malignancy of various cancers.
4/9/2023 11:39:14 PM +00:00
Circulating tumor cells detected in follow-up predict survival outcomes in tri-modality management of advanced non-metastatic esophageal cancer: A secondary analysis of the QUINTETT randomized trial
Our aim was to establish if presence of circulating tumor cells (CTCs) predicted worse outcome in patients with non-metastatic esophageal cancer undergoing tri-modality therapy. The presence of CTCs in patients during follow-up after tri-modality therapy was associated with significantly poorer DFS and OS regardless of timing of chemoradiotherapy.
4/9/2023 11:39:06 PM +00:00
Prognostic models for outcome prediction in patients with advanced hepatocellular carcinoma treated by systemic therapy: A systematic review and critical appraisal
To describe and analyze the predictive models of the prognosis of patients with hepatocellular carcinoma (HCC) undergoing systemic treatment. This study describes and analyzes the prognostic models developed and validated for patients with HCC who have undergone systemic treatment. The results show that there are some methodological flaws in the model development process, and that external validation is rarely performed.
4/9/2023 11:38:59 PM +00:00
The survival impact of palliative chemotherapy dose modifications on metastatic colon cancer
An uninterrupted dose of oxaliplatin-based cytotoxic therapy is an essential component in the standard treatment regimen of metastatic colon cancer (mCC). Data on the impacts of dose intensity reduction on the palliative treatment for patients with mCC remain scarce.
4/9/2023 11:38:52 PM +00:00
Circulating tumor cells from melanoma patients show phenotypic plasticity and metastatic potential in xenograft NOD.CB17 mice
Innovative therapies have improved the overall survival in melanoma, although a high number of patients still experience disease progression or recurrence. Ex-vivo culture of circulating tumour cells (CTCs) represents a valuable laboratory resource for in-depth characterization of rare cell populations responsible for disease progression.
4/9/2023 11:38:45 PM +00:00
N6-methyladenosine-related lncRNAs identified as potential biomarkers for predicting the overall survival of Asian gastric cancer patients
Gastric cancer (GC) is one of the most prevalent malignant tumors in Asian countries. Studies have proposed that lncRNAs can be used as diagnostic and prognostic indicators of GC due to the high specificity of lncRNAs expression involvement in GC.
4/9/2023 11:38:28 PM +00:00
Molecular pathology testing for non-small cell lung cancer: An observational study of elements currently present in request forms and result reports and the opinion of different stakeholders
For patients with non-small cell lung cancer (NSCLC), targeted therapies are becoming part of the standard treatment. It is of question which information the clinicians provide on test requests and how the laboratories adapt test conclusions to this knowledge and regulations.
4/9/2023 11:38:18 PM +00:00
Patient-centered research: How do women tolerate nipple fluid aspiration as a potential screening tool for breast cancer?
Nipple fluid aspiration (NFA) is a technique to acquire nipple aspirate fluid (NAF), which is considered a rich source of breast-specific biomarkers. Originating directly from the mammary ducts, this liquid biopsy can offer insight into the process of carcinogenesis at its earliest stage and therefore could be of added value to the current imaging-based breast cancer screening tools. With that in mind, it is necessary to know how well NFA is tolerated.
4/9/2023 11:38:09 PM +00:00
Randomized trial of surveillance with abbreviated MRI in women with a personal history of breast cancer impact on patient anxiety and cancer detection
Abbreviated breast MRI (A-MRI) substantially reduces the image acquisition and reading times and has been reported to have similar diagnostic accuracy as a full diagnostic protocol but has not been evaluated prospectively with respect to impact on psychological distress in women with a prior history of breast cancer (PHBC).
4/9/2023 11:37:58 PM +00:00
Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS)
Metastatic soft tissue sarcoma (STS) are a heterogeneous group of malignancies which are not curable with chemotherapy alone. Therefore, understanding the molecular mechanisms of sarcomagenesis and therapy resistance remains a critical clinical need.
4/9/2023 11:37:48 PM +00:00