Tài liệu miễn phí Y khoa - Dược
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Oxaliplatin-versus cisplatin-based regimens for elderly individuals with advanced gastric cancer: A retrospective cohort study
Whether an oxaliplatin- or cisplatin-based regimen is more optimal for treating elderly patients with advanced gastric cancer, in terms of survival and adverse events remains unclear.
4/9/2023 11:50:22 PM +00:00
Pharmacogenomics of in vitro response of the NCI-60 cancer cell line panel to Indian natural products
Indian natural products have been anecdotally used for cancer treatment but with limited efficacy. To better understand their mechanism, we examined the publicly available data for the activity of Indian natural products in the NCI-60 cell line panel.
4/9/2023 11:50:15 PM +00:00
Can upfront DPYD extended variant testing reduce toxicity and associated hospital costs of fuoropyrimidine chemotherapy? A propensity score matched analysis of 2022 UK patients
To independently assess the impact of mandatory testing using an extended DPYD variant panel (ToxNav®) and consequent dose adjustment of Capecitabine/5-FU on recorded quantitative toxicity, symptoms of depression, and hospital costs.
4/9/2023 11:50:07 PM +00:00
GECOP-MMC: Phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases
The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefits provided by HIPEC with oxaliplatin 460mg/m2 (30minutes) for the treatment of peritoneal metastases from colorectal cancer.
4/9/2023 11:50:00 PM +00:00
Evaluation of CSTB and DMBT1 expression in saliva of gastric cancer patients and controls
Gastric cancer (GC) is the fifth most common cancer and the third cause of cancer deaths globally, with late diagnosis, low survival rate, and poor prognosis. This case-control study aimed to evaluate the expression of cystatin B (CSTB) and deleted in malignant brain tumor 1 (DMBT1) in the saliva of GC patients with healthy individuals to construct diagnostic algorithms using statistical analysis and machine learning methods.
4/9/2023 11:49:53 PM +00:00
LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression
Abnormal expression of long non-coding RNAs (lncRNAs) has been shown to be associated with the pathogenesis of cancers, including colorectal cancer (CRC). It has been reported that LINC00022 is highly expressed in some typs of cancer and its overexpression indicates poor prognosis.
4/9/2023 11:49:43 PM +00:00
The prognostic value of weight loss during radiotherapy among patients with nasopharyngeal carcinoma: A large-scale cohort study
We aim to investigate the prognostic value of weight loss during radiotherapy (RT) among patients with nasopharyngeal carcinoma (NPC). High RT-PWL7 was significantly associated with decreased DFS, OS, and DMFS for NPC patients.
4/9/2023 11:49:36 PM +00:00
Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem-ion): Study protocol for a randomized phase II pilot trial
The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessity of amputation without compromising on overall survival rates.
4/9/2023 11:49:28 PM +00:00
Maintenance Therapy with Aromatase Inhibitor in epithelial Ovarian Cancer (MATAO): Study protocol of a randomized double-blinded placebo-controlled multi-center phase III Trial
A high percentage of epithelial ovarian cancers (EOC) express the estrogen receptor (ER), which is an ideal target for endocrine therapy. Letrozole is a proven, potent aromatase inhibitor, extensively tested and used in the treatment of ER positive breast cancer.
4/9/2023 11:49:20 PM +00:00
Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer
A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of ribosome biogenesis. Thus, ribosome biogenesis might be an innovative source of biomarkers that remains to be evaluated.
4/9/2023 11:49:11 PM +00:00
The identification of miRNA and mRNA expression profiles associated with pediatric atypical teratoid/rhabdoid tumor
Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant pediatric tumor of the central nervous system (CNS) with high recurrence and low survival rates that is often misdiagnosed. MicroRNAs (miRNAs) are involved in the tumorigenesis of numerous pediatric cancers, but their roles in AT/RT remain unclear
4/9/2023 11:49:00 PM +00:00
Prognostic biomarker SGSM1 and its correlation with immune infiltration in gliomas
Glioma was the most common type of intracranial malignant tumor. Even after standard treatment, the recurrence and malignant progression of lower-grade gliomas (LGGs) were almost inevitable. The overall survival (OS) of patients with LGG varied widely, making it critical for prognostic prediction.
4/9/2023 11:48:48 PM +00:00
Construction of in vitro 3-D model for lung cancer-cell metastasis study
Cancer metastasis is the main cause of mortality in cancer patients. However, the drugs targeting metastasis processes are still lacking, which is partially due to the short of effective in vitro model for cell invasion studies.
4/9/2023 11:48:39 PM +00:00
Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: A proposed protocol for a multicentre observational study
Standard groin treatment in recurrent vulvar cancer consists of uni- or bilateral inguinofemoral lymphadenectomy (IFL), whereas in the primary setting women with selected unifocal tumours will undergo a sentinel lymph node (SLN) procedure.
4/9/2023 11:48:31 PM +00:00
Oral cryotherapy for management of chemotherapy‐induced oral mucositis in haematopoietic cell transplantation: A systematic review
Oral mucositis (OM) is known to be the most common and challenging side effect of conditioning chemotherapy in haematopoietic cell transplant (HCT). This side effect causes significant morbidity and may delay the treatment plan, as well as increase therapeutic expenses.
4/9/2023 11:48:24 PM +00:00
Effects of HMGA2 on the epithelial-mesenchymal transition-related genes in ACHN renal cell carcinoma cells-derived xenografts in nude mice
The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2 in human renal cell carcinoma (RCC) is related with tumor invasiveness and poor prognosis.
4/9/2023 11:48:13 PM +00:00
Symptoms, problems and quality of life in patients newly diagnosed with oesophageal and gastric cancer – a comparative study of treatment strategy
Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL).
4/9/2023 11:48:03 PM +00:00
Disparities in the increases of cervical cancer incidence rates: Observations from a city-wide population-based study
Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear.
4/9/2023 11:47:56 PM +00:00
A population survey on beliefs around cervical cancer screening: Determining the barriers and facilitators associated with attendance
Cervical screening saves approximately 5000 lives annually in England. However, screening rates have been falling continuously, and coverage in London is particularly low (64.7%). While demographic predictors of uptake have been well researched, there has been less thorough investigation of the individual barriers and facilitators which predict cervical screening attendance.
4/9/2023 11:47:48 PM +00:00
Safety and effectiveness of eribulin in Japanese patients with soft tissue sarcoma including rare subtypes: A post-marketing observational study
Soft tissue sarcomas (STSs) are a heterogeneous group of cancers with over 100 described subtypes. While these cancers are infrequent, the prognosis is quite poor, particularly for those with stage IV metastatic disease.
4/9/2023 11:47:42 PM +00:00
An immune-related lncRNA pairs signature to identify the prognosis and predict the immune land
Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little is known about its relationship with the immune-related long non-coding RNA (lncRNA) pairs.
4/9/2023 11:47:33 PM +00:00
Androgen Deprivation therapy for Oligo-recurrent Prostate cancer in addition to radioTherapy (ADOPT): Study protocol for a randomised phase III trial
More than 60% of oligo-recurrent prostate cancer (PCa) patients treated with metastasis-directed radiotherapy (MDRT) develop biochemical recurrence within 2 years. This recurrence rate emphasises the need for improved treatment and patient selection. In line with the treatment of primary PCa, the efficacy of MDRT may be enhanced when combined with androgen-deprivation therapy (ADT).
4/9/2023 11:47:25 PM +00:00
Diagnostic value of tumor markers in identifying favorable or unfavorable subsets in patients with cancer of unknown primary: a retrospective study
Routine measurement of tumor markers is not recommended in daily clinical practice for patients with cancer of unknown primary (CUP). We evaluated the diagnostic value of tumor markers in identifying favorable or unfavorable subsets in patients with CUP.
4/9/2023 11:47:17 PM +00:00
Prognostic impact of angiotensin-converting enzyme inhibitors and angiotensin receptors blockers in esophageal or gastric cancer patients with hypertension - a real-world study
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by inhibiting tumor angiogenesis and proliferation.
4/9/2023 11:47:08 PM +00:00
Baseline soluble MICA levels act as a predictive biomarker for the efficacy of regorafenib treatment in colorectal cancer
To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with regorafenib activity in terms of progression-free survival (PFS) in patients with CRC.
4/9/2023 11:47:00 PM +00:00
AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer
The receptor tyrosine kinase (RTK) epidermal growth factor receptor (EGFR) is overexpressed and an important therapeutic target in Head and Neck cancer (HNC). Cetuximab is currently the only EGFR-targeting agent approved by the FDA for treatment of HNC; however, intrinsic and acquired resistance to cetuximab is a major problem in the clinic.
4/9/2023 11:46:54 PM +00:00
Comprehensive analysis of the associations between clinical factors and outcomes by machine learning, using post marketing surveillance data of cabazitaxel in patients with castration-resistant prostate cancer
We aimed to evaluate relationships between clinical outcomes and explanatory variables by network clustering analysis using data from a post marketing surveillance (PMS) study of castration-resistant prostate cancer (CRPC) patients.
4/9/2023 11:46:46 PM +00:00
OLA1 promotes colorectal cancer tumorigenesis by activation of HIF1α/CA9 axis
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors and is also the third leading cause of cancer-associated death worldwide. Various genes involved in the development of cancer pathogenesis provide novel avenues to understand the underlying molecular mechanisms that contribute to the development of CR
4/9/2023 11:46:38 PM +00:00
Exploring socio-demographic, physical, psychological, and quality of life-related factors related with fear of cancer recurrence in stomach cancer survivors: A cross-sectional study
Stomach cancer is one the most common neoplasms with high mortality. However, fear of cancer recurrence (FCR) in stomach cancer survivors has been scarcely evaluated. Thus, the aim of this study was to evaluate FCR and factors related to FCR in Korean stomach cancer survivors.
4/9/2023 11:46:31 PM +00:00
Risk factors for recurrence in elderly patients with stage II colorectal cancer: A multicenter retrospective study
Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurrence remain controversial, and there is limited information, especially for elderly patients.
4/9/2023 11:46:22 PM +00:00