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Positive H. pylori status predicts better prognosis of non-cardiac gastric cancer patients: Results from cohort study and metaanalysis
Previous researches have associated Helicobacter pylori (H. pylori) with a prognosis of gastric cancer (GC), however, without a concert conclusion. This study aimed to study this issue further by a prospective cohort study and a meta-analysis.
4/10/2023 12:24:25 AM +00:00
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes
Telomeres are protective structures at chromosome ends which shorten gradually with increasing age. In chronic lymphocytic leukemia (CLL), short telomeres have been associated with unfavorable disease outcome, but the link between clonal evolution and telomere shortening remains unresolved.
4/10/2023 12:24:19 AM +00:00
Depletion of C12orf48 inhibits gastric cancer growth and metastasis via up-regulating Poly r(C)-Binding Protein (PCBP) 1
Gastric cancer remains a major cause of cancer-related death worldwide. C12orf48, also named PARP1 binding protein, is over-expressed in several cancers. However, the expression profile and potential roles of C12orf48 in gastric cancer are largely unknown.
4/10/2023 12:24:08 AM +00:00
Quantitative proteomic analysis of GnRH agonist treated GBM cell line LN229 revealed regulatory proteins inhibiting cancer cell proliferation
Gonadotropin-releasing hormone (GnRH) receptor, a rhodopsin-like G-protein coupled receptor (GPCR) family member involved in GnRH signalling, is reported to be expressed in several tumors including glioblastoma multiforme (GBM), one of the most malignant and aggressive forms of primary brain tumors.
4/10/2023 12:24:00 AM +00:00
Deep-learning model for predicting the survival of rectal adenocarcinoma patients based on a surveillance, epidemiology, and end results analysis
We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that combined deep learning with a multilayer neural network (the DeepSurv model) for predicting the survival rate of patients with rectal adenocarcinoma.
4/10/2023 12:23:50 AM +00:00
Depressive and anxiety symptoms among Japanese cancer survivors: Japan cancer survivorship research project
This study aimed to clarify predictors of depressive symptoms and anxiety symptoms after cancer diagnosis among Japanese cancer survivors (CSs). Methods: As part of a Japanese cancer survivorship research project commissioned by the Ministry of Health, Labour and Welfare (MHLW) of Japan, we conducted a web-based nationwide survey of CSs in 2018.
4/10/2023 12:23:43 AM +00:00
Polymorphisms in autophagy genes are genetic susceptibility factors in glioblastoma development
Glioblastoma is the most aggressive and common malignant primary brain tumor in adults. Many genetic, epigenetic and genomic mutations have been identified in this tumor, but no driving cause has been identified yet for glioblastoma pathogenesis.
4/10/2023 12:23:33 AM +00:00
Dosimetric analysis of radiation-induced brainstem necrosis for nasopharyngeal carcinoma treated with IMRT
Radiation-induced brainstem necrosis (RIBN) is a late life-threatening complication that can appear after treatment in patients with nasopharyngeal carcinoma (NPC). However, the relationship between RIBN and radiation dose is not still well-defined.
4/10/2023 12:23:26 AM +00:00
Identification of a glycolysis-related gene signature for predicting prognosis in patients with hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer in the world. Although great advances in HCC diagnosis and treatment have been achieved, due to the complicated mechanisms in tumor development and progression, the prognosis of HCC is still dismal.
4/10/2023 12:23:12 AM +00:00
Perception of information to Swedish melanoma patients in routine clinical practice – a cross-sectional survey
Comprehensible, relevant information empowers patients, allowing them to take an active part in their care. We aim to investigate how Swedish melanoma patients perceive information provided in routine clinical practice and explore the correlation between satisfaction with information, symptoms and functioning scales, and quality of life.
4/10/2023 12:23:01 AM +00:00
Acceptability and safety of thermal ablation to prevent cervical cancer in sub-Saharan Africa
The World Health Organization recommends thermal ablation as an alternative to cryotherapy to treat women with precancerous lesions in low-resource settings. However, limited data are available on women’s experience and adverse events (AEs) of the procedure in the context of Sub-Saharan Africa.
4/10/2023 12:22:51 AM +00:00
Thrombospondin-2 holds prognostic value and is associated with metastasis and the mismatch repair process in gastric cancer
This study aims to investigate thrombospondin 2 (TSP2) expression levels in gastric cancer (GC) and determine the relationship between TSP2 and clinical characteristics and prognosis.
4/10/2023 12:22:40 AM +00:00
Angiotensin blockade therapy and survival in pancreatic cancer: A population study
Pancreatic cancer (PC) is one of the most aggressive and challenging cancer types to effectively treat, ranking as the fourth-leading cause of cancer death in the United States. We investigated if exposures to angiotensin II receptor blockers (ARBs) or angiotensin I converting enzyme (ACE) inhibitors after PC diagnosis are associated with survival.
4/10/2023 12:22:32 AM +00:00
Uncovering potential genes in colorectal cancer based on integrated and DNA methylation analysis in the gene expression omnibus database
Colorectal cancer (CRC) is major cancer-related death. The aim of this study was to identify differentially expressed and differentially methylated genes, contributing to explore the molecular mechanism of CRC.
4/10/2023 12:22:25 AM +00:00
Longitudinal minimal residual disease assessment in multiple myeloma patients in complete remission – results from the NMSG flow-MRD substudy within the EMN02/HO95 MM trial
Multiple myeloma remains an incurable disease with multiple relapses due to residual myeloma cells in the bone marrow of patients after therapy. Presence of small number of cancer cells in the body after cancer treatment, called minimal residual disease, has been shown to be prognostic for progression-free and overall survival.
4/10/2023 12:22:18 AM +00:00
Prevalence of specific and recurrent/founder pathogenic variants in BRCA genes in breast and ovarian cancer in North Africa
Elucidation of specific and recurrent/founder pathogenic variants (PVs) in BRCA (BRCA1 and BRCA2) genes can make the genetic testing, for breast cancer (BC) and/or ovarian cancer (OC), affordable for developing nations.
4/10/2023 12:22:07 AM +00:00
Pre-clinical and clinical studies on the role of RBM3 in muscle-invasive bladder cancer: Longitudinal expression, transcriptome-level effects and modulation of chemosensitivity
The response to neoadjuvant cisplatin-based chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC) is impaired in up to 50% of patients due to chemoresistance, with no predictive biomarkers in clinical use.
4/10/2023 12:21:59 AM +00:00
Baseline blood count levels increase odds of cytopenia among CML patients in Kenya: A case control study
Imatinib is the gold standard for the treatment of all phases of Philadelphia positive Chronic Myeloid Leukemia (CML). During treatment, patients may develop cytopenia. We aimed to study the baseline characteristics and factors associated with cytopenia at a Nairobi Hospital.
4/10/2023 12:21:53 AM +00:00
Infuence of early colorectal cancer component on the positive margins after endoscopic resection: A retrospective study
Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC confined in the mucosa.
4/10/2023 12:21:46 AM +00:00
Number of negative lymph nodes with a positive impact on survival of stage III colon cancer; A retrospective observation study for right side and left side colon
The purpose was to examine the effect of negative lymph nodes (NLN) number on survival in stage III colon cancer. To reduce the interference of acute inflammation, we included patients with stage III colon cancer who had undergone elective surgery and excluded those who had tumor perforation, obstruction, ischemia, or massive tumor bleeding.
4/10/2023 12:21:38 AM +00:00
Late effects of high-dose methotrexate treatment in childhood cancer survivors-a systematic review
High-dose methotrexate (HD-MTX) is used in the treatment of different childhood cancers, including leukemia, the most common cancer type and is commonly defined as an intravenous dose of at least 1 g/m2 body surface area per application. A systematic review on late effects on different organs due to HD-MTX is lacking.
4/10/2023 12:21:31 AM +00:00
Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer
Gastric cancer is a heterogeneous disease with poorly understood genetic and microenvironmental factors. Mutations in collagen genes are associated with genetic diseases that compromise tissue integrity, but their role in tumor progression has not been extensively reported.
4/10/2023 12:21:21 AM +00:00
Improved automated early detection of breast cancer based on high resolution 3D micro-CT microcalcification images
The detection of suspicious microcalcifications on mammography represents one of the earliest signs of a malignant breast tumor. Assessing microcalcifications’ characteristics based on their appearance on 2D breast imaging modalities is in many cases challenging for radiologists.
4/10/2023 12:21:11 AM +00:00
Ceftazidime and cefepime antagonize 5-fuorouracil’s effect in colon cancer cells
Drug-drug interaction (DDI), which can occur at the pharmacokinetics and/or the pharmacodynamics (PD) levels, can increase or decrease the therapeutic or adverse response of a drug itself or a combination of drugs. Cancer patients often receive, along their antineoplastic agents, antibiotics such as ß-lactams to treat or prevent infection.
4/10/2023 12:21:03 AM +00:00
Colorectal cancer community engagement: A qualitative exploration of American Indian voices from North Dakota
American Indians (AI) in North Dakota present with higher rates of advanced-stage disease for screening detectable colorectal cancers and have lower overall baseline colorectal cancer screening rates than non-AIs.
4/10/2023 12:20:56 AM +00:00
Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis
Ovarian cancer (OC) is a female malignant tumor with a high fatality rate. Long non-coding RNAs (lncRNAs) are deeply involved in OC progression. The aim of this study is to explore the specific mechanism of lncRNA prostate androgen-regulated transcript 1 (PART1) in OC.
4/10/2023 12:20:46 AM +00:00
The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer
Findings from numerous studies have revealed that ferroptosis is closely related to tumorigenesis and immune cell infiltration. Long non-coding RNAs (lncRNAs) are reportedly involved in the progression of various cancers, including prostate cancer (PCa).
4/10/2023 12:20:38 AM +00:00
Feasibility and thematic analysis of narrative visualization materials with physical activity monitoring among breast cancer survivors
Breast cancer survivors have a unique risk for negative health outcomes. Engaging in routine physical activity (PA) can reduce these risks. However, PA levels are low among this population. Narrative visualization (NV) is a technique that uses drawings, photographs, and text to contextualize data, which may increase integrated regulation, or motivation related to personal values and identity.
4/10/2023 12:20:27 AM +00:00
Incidence trends of childhood central nervous system tumors in Finland 1990–2017
Central nervous system (CNS) tumors are a leading cause of cancer-related morbidity and mortality in children. Our aim is to characterize incidence trends of pediatric CNS tumors in Finland over the last three decades.
4/10/2023 12:20:20 AM +00:00
Cancer risk in persons with new-onset anaemia: A population-based cohort study in Denmark
The time interval from first symptom and sign until a cancer diagnosis significantly affects the prognosis. Therefore, recognising and acting on signs of cancer, such as anaemia, is essential.
4/10/2023 12:20:11 AM +00:00