Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer
Longitudinal profiling of circulating tumour DNA for tracking tumour dynamics in pancreatic cancer
The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to characterise and track patient-specific somatic ctDNA variants, to assess longitudinal changes in disease burden and explore the landscape of actionable alterations.