Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate.