Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta (TOP2B) facilitates rapid gene expression and functions at the later stages of development and differentiation.