TOAST: Improving reference-free cell composition estimation by cross-cell type differential analysis
TOAST: Improving reference-free cell composition estimation by cross-cell type differential analysis
In the analysis of high-throughput data from complex samples, cell composition is an important factor that needs to be accounted for. Except for a limited number of tissues with known pure cell type profiles, a majority of genomics and epigenetics data relies on the “reference-free deconvolution” methods to estimate cell composition.