The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
The first enhancer in an enhancer chain safeguards subsequent enhancer-promoter contacts from a distance
Robustness and evolutionary stability of gene expression in the human genome are established by an array of redundant enhancers. Results: Using Hi-C data in multiple cell lines, we report a comprehensive map of promoters and active enhancers connected by chromatin contacts, spanning 9000 enhancer chains in 4 human cell lines associated with 2600 human genes.