Synthesis of novel 1,2,4-triazoles and triazolo-thiadiazines as anticancer agents
Synthesis of novel 1,2,4-triazoles and triazolo-thiadiazines as anticancer agents
In addition, the novel bis-(1,2,4-triazole-3-thione) was reacted with the appropriate hydrazonoyl chloride in dioxane under reflux in the presence of triethylamine to give the corresponding bis-(1,2,4-triazolethiohydrazonoate). The structures of the new compounds were established based on elemental and spectral data. The mechanism of the studied reaction was also discussed. Moreover, some of the new products were screened for their anticancer activity and the results obtained are promising and i