Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from N -(arylsulfonyl)methionine
Synthesis, and prediction of molecular properties and antimicrobial activity of some acylhydrazones derived from N -(arylsulfonyl)methionine
The MIC value of compound 30 against Enterococcus faecalis, Listeria monocytogenes, and Bacillus cereus was 8 µg/mL. A computational study for prediction of ADME and drug-like properties (solubility, drug-likeness, and drug score) as well as potential toxicity profiles of compounds 2–40 was performed using the Molinspiration online property calculation toolkit and Osiris Property Explorer. As most of our compounds meet Lipinski’s rule of five, they promise good solubility and permeability. Accor