Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm
Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification. However, it is not fully understood how individual stem cells exit the pluripotent state and transition towards their respective progenitor states.