SiFit: Inferring tumor trees from single-cell sequencing data under finite-sites models
SiFit: Inferring tumor trees from single-cell sequencing data under finite-sites models
Single-cell sequencing enables the inference of tumor phylogenies that provide insights on intra-tumor heterogeneity and evolutionary trajectories. Recently introduced methods perform this task under the infinite-sites assumption, violations of which, due to chromosomal deletions and loss of heterozygosity, necessitate the development of inference methods that utilize finite-sites models.