Reproducible inference of transcription factor footprints in ATAC-seq and DNaseseq datasets using protocol-specific bias modeling
Reproducible inference of transcription factor footprints in ATAC-seq and DNaseseq datasets using protocol-specific bias modeling
DNase-seq and ATAC-seq are broadly used methods to assay open chromatin regions genome-wide. The single nucleotide resolution of DNase-seq has been further exploited to infer transcription factor binding sites (TFBSs) in regulatory regions through footprinting.