Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer
Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer
The mutational processes underlying non-coding cancer mutations and their biological significance in tumor evolution are poorly understood. To get better insights into the biological mechanisms of mutational processes in breast cancer, we integrate whole-genome level somatic mutations from breast cancer patients with chromatin states and transcription factor binding events.