MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells
MicroRNAs control mRNA fate by compartmentalization based on 3′ UTR length in male germ cells
Post-transcriptional regulation of gene expression can be achieved through the control of mRNA stability, cytoplasmic compartmentalization, 3′ UTR length and translational efficacy. Spermiogenesis, a process through which haploid male germ cells differentiate into spermatozoa, represents an ideal model for studying posttranscriptional regulation in vivo because it involves a large number of transcripts that are physically sequestered in ribonucleoprotein particles (RNPs) and thus subjected to de