MARZ: An algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
MARZ: An algorithm to combinatorially analyze gapped n-mer models of transcription factor binding
A key challenge in understanding the molecular mechanisms that control gene regulation is the characterization of the specificity with which transcription factor proteins bind to specific DNA sequences. A number of computational approaches have been developed to examine these interactions, including simple mononucleotide and dinucleotide position weight matrix models.