Kourami: Graph-guided assembly for novel human leukocyte antigen allele discovery
Kourami: Graph-guided assembly for novel human leukocyte antigen allele discovery
Accurate typing of human leukocyte antigen (HLA) is important because HLA genes play important roles in immune responses and disease genesis. Previously available computational methods are database-matching approaches and their outputs are inherently limited by the completeness of already known types, making them unsuitable for discovery of novel alleles.