Improvement of solubility of celecoxib by inclusion in MCM-41 mesoporous silica: drug loading and release
Improvement of solubility of celecoxib by inclusion in MCM-41 mesoporous silica: drug loading and release
Celecoxib is a poorly water-soluble nonsteroidal anti-inflammatory drug. Here we report four ordered mesoporous silica MCM-41 supports with different particle size, pore volume, and surface properties to investigate their loading capacity with celecoxib and their release abilities. Spherical MCM-41 mesoporous supports less than 50 nm in diameter were prepared and to compare the effect of the template removal process on morphology of samples, acid extraction and calcination methods were used. Mor