High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells
High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local transcriptional potential.