High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood DNA methylation at approximately 4.5 million loci, each comprising 2.9 CpGs on average, in 697 normal subjects.