Genetic regulation of gene expression and splicing during a 10-year period of human aging
Genetic regulation of gene expression and splicing during a 10-year period of human aging
Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterization of these molecular changes, especially in older age.