Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies
Estimating and accounting for tumor purity in the analysis of DNA methylation data from cancer studies
We present a set of statistical methods for the analysis of DNA methylation microarray data, which account for tumor purity. These methods are an extension of our previously developed method for purity estimation; Our updated method is flexible, efficient, and does not require data from reference samples or matched normal controls.