DESE: Estimating driver tissues by selective expression of genes associated with complex diseases or traits
DESE: Estimating driver tissues by selective expression of genes associated with complex diseases or traits
The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of diseaseassociated genes in genome-wide association studies (GWASs).