Depletion of somatic mutations in splicingassociated sequences in cancer genomes
Depletion of somatic mutations in splicingassociated sequences in cancer genomes
An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identification of false-positive mutations.