Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains
Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains
CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stability remains elusive.