Clonealign: Statistical integration of independent single-cell RNA and DNA sequencing data from human cancers
Clonealign: Statistical integration of independent single-cell RNA and DNA sequencing data from human cancers
Measuring gene expression of tumor clones at single-cell resolution links functional consequences to somatic alterations. Without scalable methods to simultaneously assay DNA and RNA from the same single cell, parallel single-cell DNA and RNA measurements from independent cell populations must be mapped for genome-transcriptome association.