Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline
Chromatin loops form a basic unit of interphase nuclear organization, with chromatin loop anchor points providing contacts between regulatory regions and promoters. However, the mutational landscape at these anchor points remains under-studied. Here, we describe the unusual patterns of somatic mutations and germline variation associated with loop anchor points and explore the underlying features influencing these patterns.