Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay
Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay
Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase assays require thousands to millions of fresh cells for comprehensive chromatin mapping.