CB2 improves power of cell detection in droplet-based single-cell RNA sequencing data
CB2 improves power of cell detection in droplet-based single-cell RNA sequencing data
An important challenge in pre-processing data from droplet-based single-cell RNA sequencing protocols is distinguishing barcodes associated with real cells from those binding background reads. Existing methods test barcodes individually and consequently do not leverage the strong cell-to-cell correlation present in most datasets.