Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
The 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry in non-African populations; Yet, strong evidence of positive selection in the OAS region is still lacking.