3DeFDR: Statistical methods for identifying cell type-specific looping interactions in 5C and Hi-C data
3DeFDR: Statistical methods for identifying cell type-specific looping interactions in 5C and Hi-C data
An important unanswered question in chromatin biology is the extent to which long-range looping interactions change across developmental models, genetic perturbations, drug treatments, and disease states. Computational tools for rigorous assessment of cell type-specific loops across multiple biological conditions are needed.