This chapter introduces a project named eDiamond, which aims to develop a Grid-enabled federated database of annotated mammograms, built at a number of sites (initially in the United Kingdom), and which ensures database consistency and reliable image processing. A key feature of eDiamond is that images are ‘standardised’ prior to storage. Section 41.3 describes what this means, and why it is a fundamental requirement for numerous grid applications, particularly in medical image analysis, and esp