Fluid Bed Particle Processing

Peter Dybdahl Hede Fluid Bed Particle Processing Ventus www.ventus.dk Download free ebooks at bookboon.com Fluid Bed Particle Processing Contents Contents Fluid Bed Particle Processing 5 1. Introduction to fluid bed processing 6 1.2 Important fluid bed parameters 8 1.3 The Geldart classification of particles 9 1.4 Advantages and disadvantages of fluid bed operations 11 2. The process and principles of Wet agglomeration 12 2.1 Introduction to the stages of the granulation processes 12 2.2 Wetting and nucleation 13 2.2.1 Nucleation thermodynamics 14 2.2.2 Nucleus formation kinetics 15 2.2.3 Binder dispersion 18 2.2.4 Nucleation regime map 20 2.3 Granule growth behavior 21 2.3.1 Granule coalescence 21 2.3.2 Eff. of diff. process and formulation param. on granule growth behav. 24 2.4 Breakage and attrition 26 2.5 Simulation of the aggl. – a brief review on population balance theory 26 2.6 Summing up on wet aggl. – Qual. guidelines for param. influencing aggl. 27 3. Granule coating principles and properties in fl uid beds 30 3.1 Parameters describing the coating process and result 31 3.2 Product, system and operating param. Aff. the coating process and effic. 31 3.3 Influence of product and formulation vari. on coated granule morphology 34 3.4 Aggl. or Coating?? – Qual. trends and attempts of find. a boundary param. 35 3.5 Qualitative description of key parameters governing the coating process 37 The next step for top-performing graduates Masters in Management Designed for high-achieving graduates across all disciplines, London Business School’s Masters in Management provides specific and tangible foundations for a successful career in business. This 12-month, full-time programme is a business qualification with impact. In 2010, our MiM employment rate was 95% within 3 months of graduation*; the majority of graduates choosing to work in consulting or financial services. 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Mech. prop. of gran. and coating layer – strength and breakage mech. 4.1 Properties characterising the granule strength 4.2 Types of breakage mechanisms 4.3 Towards a quantitative prediction of breakage mechanisms 4.4 Qualitative trends of parameters affecting breakage 4.5 Modern approach – a brief rev. on computer sim. of granule breakage 4.6 Strength test methods – a brief review 4.6.1 Bulk test methods 4.6.2 Single particle test methods 4.7 Summing up on granule strength Contents 39 39 41 44 46 47 47 47 49 49 5. Summary 51 Table of symbols 52 Literature 57 Appendix A1: Derivation of the equation 2.5 65 Appendix A2: From equation 2.5 to equation 2.7 69 Appendix A3: Derivation of the dimensionless spray fl ux 70 Appendix A4: Deriv. of Stokes viscous no. and Stokes critical viscous no. 71 Appendix A5: Derivation of equation 3.1 describing the coating thickness 74 Appendix A6: Derivation of equation 3.4 76 Notes 79 Teach with the Best. Learn with the Best. Agilent offers a wide variety of affordable, industry-leading electronic test equipment as well as knowledge-rich, on-line resources —for professors and students. We have 100’s of comprehensive web-based teaching tools, lab experiments, application notes, brochures, DVDs/ CDs, posters, and more. © Agilent Technologies, Inc. 2012 See what Agilent can do for you. www.agilent.com/find/EDUstudents www.agilent.com/find/EDUeducators u.s. 1-800-829-4444 canada: 1-877-894-4414 Download free ebooks at bookboon.com 4 Fluid Bed Particle Processing Fluid Bed Particle Processing The present text introduces the use of fluidised bed processing in the context of wet granulation and coating. The text also covers introductory information about the mechanical properties of dry granules. This is a scientific field rarely taught at universities or engineering schools around the world although it has enormous and ever increasing relevance to the chemical and biochemical industries. Often students are left with nothing but qualitative tendencies and hands-on experience as no textbook yet covers all relevant subjects treated in this text. Being part of the powder technology field it is the aim of this text to narrow the gap between applied engineering and quantitative models and theory. The text is aimed at undergraduate university or engineeringschool students working in the field of chemical or biochemical engineering. Newly graduated as well as experienced engineers may also find relevant new information as emphasis is put on the newest scientific discoveries and proposals presented in recent years of scientific publications. In order to provide a firm theoretical background several of the relevant formulas have been derived in the appendix which is often impossible to find elsewhere even in scientific literature. It is the hope that such theoretical considerations may help the reader to understand how particle technology is closely related to other branches of chemical science and chemical engineering. The literature list may also hopefully be an inspiration for further reading in the small but highly important field of fluid bed processing. I alone am responsible for any misprints or errors but I will be grateful to receive any critics and suggestions for improvements. Copenhagen, September 2006 Peter Dybdahl Hede Download free ebooks at bookboon.com 5 ... - tailieumienphi.vn