Response: Sharpe, Goldsmith and Chalder fail to restore confidence in the PACE trial findings
Response: Sharpe, Goldsmith and Chalder fail to restore confidence in the PACE trial findings
In a recent paper, we argued that the conclusions of the PACE trial of chronic fatigue syndrome are problematic because the pre-registered protocol was not adhered to. We showed that when the originally specific outcomes and analyses are used, the evidence for the effectiveness of CBT and graded exercise therapy is weak.