Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Dogs develop cancer spontaneously with age, with breed-specific risk underlying differences in genetics. Mammary tumors are reported as the most frequent neoplasia in intact female dogs. Their high prevalence in certain breeds suggests a genetic component, as it is the case in human familial breast cancer, distinctly in BRCA2-associated cancers.