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15 Vascular Resection for Hepatocellular Carcinoma 255 perform these resections. More importantly, such surgeons should understand the risks, benefits and limitations of these highly aggressive procedures and that they should be applied to a highly selected group of patients. An even smaller subset of patients with tumors involving major vasculature may be considered for resections utilizing cold preservations techniques. These extreme resections, performed by a handful of surgeons, offer the only hope for patients who would otherwise succumb to their liver cancers. The utility of these “extreme operations” must be carefully considered on a case-by-case basis. References 1. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362(9399): 1907–1917 2. Tsai TJ, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hsia CY, Wu CW (2000) Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery 127:603–608 3. Sugino T, Yamaguchi T, Hoshi N, Kusakabe T, Ogura G, Goodison S, Suzuki T (2008) Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis. Clin Exp Metastasis 25:835–841 4. Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJ (2000) Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nat Med 6:100–102 5. Mitsunobu M, Toyosaka A, Oriyama T, Okamoto E, Nakao N (1996) Intrahepatic metas-tases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel. Clin Exp Metastasis 14:520–529 6. Inoue Y, Hasegawa K, Ishizawa T, Aoki T, Sano K, Beck Y, Imamura H, Sugawara Y, Kokudo N, Makuuchi M (2009) Is there any difference in survival according to the por-tal tumor thrombectomy method in patients with hepatocellular carcinoma? Surgery 145: 9–19 7. Liotta LA, Saidel MG, Kleinerman J (1976) The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36:889–894 8. Weiss L, Orr FW, Honn KV (1989) Interactions between cancer cells and the microvascula-ture: a rate-regulator for metastasis Clin Exp Metastasis 7:127–167 9. KimBK,HanKH,ParkYN,ParkMS,KimKS,ChoiJS,MoonBS,ChonCY,MoonYM,Ahn SH (2008) Prediction of microvascular invasion before curative resection of hepatocellular carcinoma. J Surg Oncol 97:246–252 10. Matsuda M, Suzuki T, Kono H, Fujii H (2007) Predictors of hepatic venous trunk invasion and prognostic factors in patients with hepatocellular carcinomas that had come into contact with the trunk of major hepatic veins. J Hepatobiliary Pancreat Surg 14:289–296 11. Hagiwara S, Kudo M, Kawasaki T, Nagashima M, Minami Y, Chung H, Fukunaga T, Kitano M, Nakatani T (2006) Prognostic factors for portal venous invasion in patients with hepatocellular carcinoma. J Gastroenterol 41:1214–1219 12. Adachi E, Maeda T, Kajiyama K, Kinukawa N, Matsumata T, Sugimachi K, Tsuneyoshi M (1996) Factors correlated with portal venous invasion by hepatocellular carcinoma: univari-ate and multivariate analyses of 232 resected cases without preoperative treatments. Cancer 77:2022–2031 13. Poon RT, Fan ST, Lo CM, Liu CL, Lam CM, Yuen WK, Yeung C, Wong J (2004) Improving perioperative outcome expands the role of hepatectomy in management of benign and malig-nanthepatobiliarydiseases:analysisof1222consecutivepatientsfromaprospectivedatabase. Ann Surg 240:698–708 256 R.D. Kim and A.W. Hemming 14. Llovet JM, Schwartz M, Mazzaferro V (2005) Resection and liver transplantation for hepatocellular carcinoma. Semin Liver Dis 25:181–200 15. Farges O, Belghiti J, Kianmanesh R, Regimbeau JM, Santoro R, Vilgrain V, Denys A, Sauvanet A (2003) Portal vein embolization before right hepatectomy: prospective clinical trial. Ann Surg 237:208–217 16. Azoulay D, Castaing D, Krissat J, Smail A, Hargreaves GM, Lemoine A, Emile JF, Bismuth H (2000) Percutaneous portal vein embolization increases the feasibility and safety of major liver resection for hepatocellular carcinoma in injured liver. Ann Surg 232: 665–672 17. Hemming AW, Reed AI, Howard RJ, Fujita S, Hochwald SN, Caridi JG, Hawkins IF, Vauthey JN (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg 237:686–691 18. Palavecino M, Chun YS, Madoff DC, Zorzi D, Kishi Y, Kaseb AO, Curley SA, Abdalla EK, Vauthey JN (2009) Major hepatic resection for hepatocellular carcinoma with or without portal vein embolization: Perioperative outcome and survival. Surgery 145: 399–405 19. Bruix J, Castells A, Bosch J, Feu F, Fuster J, Garcia-Pagan JC, Visa J, Bru C, Rodes J (1996) Surgical resection of hepatocellular carcinoma in cirrhotic patients: prognostic value of preoperative portal pressure. Gastroenterology 111:1018–1022 20. Llovet JM (2005) Updated treatment approach to hepatocellular carcinoma. J Gastroenterol 40:225–235 21. Noun R, Jagot P, Farges O, Sauvanet A, Belghiti J (1997) High preoperative serum alanine transferaselevels:effectontheriskofliverresectioninChildgradeAcirrhoticpatients.World J Surg 21:390–394 22. Eguchi H, Umeshita K, Sakon M, Nagano H, Ito Y, Kishimoto SI, Dono K, Nakamori S, Takeda T, Gotoh M, Wakasa K, Matsuura N, Monden M (2000) Presence of active hepatitis associated with liver cirrhosis is a risk factor for mortality caused by posthepatectomy liver failure. Dig Dis Sci 45:383–388 23. Lang H, Radtke A, Liu C, Fruhauf NR, Peitgen HO, Broelsch CE (2004) Extended left hep-atectomy – modified operation planning based on three-dimensional visualization of liver anatomy. Langenbecks Arch Surg 389:306–310 24. Rossi S, Ghittoni G, Ravetta V, Torello VF, Rosa L, Serassi M, Scabini M, Vercelli A, Tinelli C, Dal BB, Burns PN, Calliada F (2008) Contrast-enhanced ultrasonography and spiral com-putedtomographyinthedetectionandcharacterizationofportalveinthrombosiscomplicating hepatocellular carcinoma. Eur Radiol 18:1749–1756 25. Miyata R, Tanimoto A, Wakabayashi G, Shimazu M, Nakatsuka S, Mukai M, Kitajima M (2006) Accuracy of preoperative prediction of microinvasion of portal vein in hep-atocellular carcinoma using superparamagnetic iron oxide-enhanced magnetic resonance imaging and computed tomography during hepatic angiography. J Gastroenterol 41: 987–995 26. Togo S, Shimada H, Kanemura E, Shizawa R, Endo I, Takahashi T, Tanaka K (1998) Usefulness of three-dimensional computed tomography for anatomic liver resection: sub-subsegmentectomy. Surgery 123:73–78 27. Yamanaka J, Saito S, Fujimoto J (2007) Impact of preoperative planning using virtual segmental volumetry on liver resection for hepatocellular carcinoma. World J Surg 31: 1249–1255 28. Lang H, Radtke A, Hindennach M, Schroeder T, Fruhauf NR, Malago M, Bourquain H, Peitgen HO, Oldhafer KJ, Broelsch CE (2005) Impact of virtual tumor resection and computer-assisted risk analysis on operation planning and intraoperative strategy in major hepatic resection. Arch Surg 140:629–638 29. Chen H, Merchant NB, Didolkar MS (2000) Hepatic resection using intermittent vascu-lar inflow occlusion and low central venous pressure anesthesia improves morbidity and mortality. J Gastrointest Surg 4:162–167 15 Vascular Resection for Hepatocellular Carcinoma 257 30. Soonawalla ZF, Stratopoulos C, Stoneham M, Wilkinson D, Britton BJ, Friend PJ (2008) Role ofthereverse-Trendelenberg patientpositioninmaintaininglow-CVPanaesthesiaduringliver resections. Langenbecks Arch Surg 393:195–198 31. Huguet C, Gavelli A, Bona S (1994) Hepatic resection with ischemia of the liver exceeding one hour. J Am Coll Surg 178:454–458 32. Hannoun L, Delriviere L, Gibbs P, Borie D, Vaillant JC, Delva E (1996) Major extended hepatic resections in diseased livers using hypothermic protection: preliminary results from the first 12 patients treated with this new technique. J Am Coll Surg 183:597–605 33. Man K, Fan ST, Ng IO, Lo CM, Liu CL, Wong J (1997) Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. Ann Surg 226: 704–711 34. Clavien PA, Selzner M, Rudiger HA, Graf R, Kadry Z, Rousson V, Jochum W (2003) A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg 238:843–850 35. Serafin A, Fernandez-Zabalegui L, Prats N, Wu ZY, Rosello-Catafau J, Peralta C (2004) Ischemicpreconditioning:tolerancetohepaticischemia-reperfusioninjury.HistolHistopathol 19:281–289 36. Gurusamy KS, Kumar Y, Pamecha V, Sharma D, Davidson BR (2009) Ischaemic pre-conditioning for elective liver resections performed under vascular occlusion. Cochrane Database Syst Rev Jan 21(1):CD007629 37. Nakashima T, Okuda K, Kojiro M, Jimi A, Yamaguchi R, Sakamoto K, Ikari T (1983) Pathology of hepatocellular carcinoma in Japan. 232 Consecutive cases autopsied in ten years. Cancer 51:863–877 38. Anthony PP (1973) Primary carcinoma of the liver: a study of 282 cases in Ugandan Africans. J Pathol 110:37–48 39. Sung AD, Cheng S, Moslehi J, Scully EP, Prior JM, Loscalzo J (2008) Hepatocellular carci-noma with intracavitary cardiac involvement: a case report and review of the literature. Am J Cardiol 102:643–645 40. Agelopoulou P, Kapatais A, Varounis C, Grassos C, Kalkandi E, Kouris N, Pierakeas N, Babalis D (2007) Hepatocellular carcinoma with invasion into the right atrium. Report of two cases and review of the literature. Hepatogastroenterology 54:2106–2108 41. Kubota K, Makuuchi M, Kobayashi T, Sakamoto Y, Inoue K, Torzilli G, Takayama T (1997) Reconstruction of the inferior vena cava using a hepatic venous patch obtained from resected liver. Hepatogastroenterology 44:378–379 42. Miyazaki M, Ito H, Kimura F, Shimizu H, Togawa A, Ohtsuka M, Yoshidome H, Kato A, Yoshitomi H, Sawada S, Ambiru S (2004) Hepatic vein reconstruction using autologous vein graft for resection of advanced hepatobiliary malignancy. Hepatogastroenterology 51: 1581–1585 43. Ohwada S, Ogawa T, Kawashima Y, Ohya T, Kobayashi I, Tomizawa N, Otaki A, Takeyoshi I, Nakamura S, Morishita Y (1999) Concomitant major hepatectomy and inferior vena cava reconstruction. J Am Coll Surg 188:63–71 44. Iwatsuki S, Todo S, Starzl TE (1988) Right trisegmentectomy with a synthetic vena cava graft. Arch Surg 123:1021–1022 45. Kumada K, Shimahara Y, Fukui K, Itoh K, Morikawa S, Ozawa K (1988) Extended right hepatic lobectomy: combined resection of inferior vena cava and its reconstruction by EPTFE graft (Gore-Tex). Case report. Acta Chir Scand 154:481–483 46. Bower TC, Nagorney DM, Cherry KJ, Jr., Toomey BJ, Hallett JW, Panneton JM, Gloviczki P (2000) Replacement of the inferior vena cava for malignancy: an update. J Vasc Surg 31: 270–281 47. Risher WH, Arensman RM, Ochsner JL, Hollier LH (1990) Retrohepatic vena cava recon-struction with polytetrafluoroethylene graft. J Vasc Surg 12:367–370 48. Miller CM, Schwartz ME, Nishizaki T (1991) Combined hepatic and vena caval resection with autogenous caval graft replacement. Arch Surg 126:106–108 258 R.D. Kim and A.W. Hemming 49. Hashimoto T, Minagawa M, Aoki T, Hasegawa K, Sano K, Imamura H, Sugawara Y, Makuuchi M, Kokudo N (2008) Caval invasion by liver tumor is limited. J Am Coll Surg 207:383–392 50. Smyrniotis V, Kostopanagiotou G, Lolis E, Theodoraki K, Farantos C, Andreadou I, Polymeneas G, Genatas C, Contis J (2003) Effects of hepatovenous back flow on ischemic-reperfusion injuries in liver resections with the pringle maneuver. J Am Coll Surg 197: 949–954 51. Fortner JG, Shiu MH, Kinne DW, Kim DK, Castro EB, Watson RC, Howland WS, Beattie EJ Jr (1974) Major hepatic resection using vascular isolation and hypothermic perfusion. Ann Surg 180:644–652 52. Pichlmayr R, Bretschneider HJ, Kirchner E, Ringe B, Lamesch P, Gubernatis G, Hauss J, Niehaus KJ, Kaukemuller J (1988) [Ex situ operation on the liver. A new possibility in liver surgery]. Langenbecks Arch Chir 373:122–126 53. Hemming AW, Nelson DR, Reed AI (2002) Liver transplantation for hepatocellular carci-noma. Minerva Chir 57:575–585 54. Hemming AW, Reed AI, Langham MR, Jr., Fujita S, Howard RJ (2004) Combined resection of the liver and inferior vena cava for hepatic malignancy. Ann Surg 239:712–719 55. Azoulay D, Eshkenazy R, Andreani P, Castaing D, Adam R, Ichai P, Naili S, Vinet E, Saliba F, Lemoine A, Gillon MC, Bismuth H (2005) In situ hypothermic perfusion of the liver versus standard total vascular exclusion for complex liver resection. Ann Surg 241:277–285 56. Gubernatis G, Pichlmayr R, Lamesch P, Grosse H, Bornscheuer A, Meyer HJ, Ringe B, Farle M, Bretschneider HJ (1990) HTK-solution (Bretschneider) for human liver transplantation. First clinical experiences. Langenbecks Arch Chir 375:66–70 57. Kalayoglu M, Sollinger HW, Stratta RJ, D’Alessandro AM, Hoffmann RM, Pirsch JD, Belzer FO (1988) Extended preservation of the liver for clinical transplantation. Lancet 1(8586): 617–619 58. Melendez J, Ferri E, Zwillman M, Fischer M, DeMatteo R, Leung D, Jarnagin W, Fong Y, Blumgart LH (2001) Extended hepatic resection: a 6-year retrospective study of risk factors for perioperative mortality. J Am Coll Surg 192:47–53 59. Oldhafer KJ, Lang H, Schlitt HJ, Hauss J, Raab R, Klempnauer J, Pichlmayr R (2000) Long-term experience after ex situ liver surgery. Surgery 127:520–527 60. Gotohda N, Kinoshita T, Konishi M, Nakagohri T, Takahashi S, Furuse J, Ishii H, Yoshino M (2006) New indication for reduction surgery in patients with advanced hepatocellular carcinoma with major vascular involvement. World J Surg 30:431–438 61. MinagawaM,MakuuchiM,TakayamaT,OhtomoK(2001)Selectioncriteriaforhepatectomy in patients with hepatocellular carcinoma and portal vein tumor thrombus. Ann Surg 233: 379–384 62. Imamura H, Matsuyama Y, Tanaka E, Ohkubo T, Hasegawa K, Miyagawa S, Sugawara Y, Minagawa M, Takayama T, Kawasaki S, Makuuchi M (2003) Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy. J Hepatol 38:200–207 63. Ercolani G, Grazi GL, Ravaioli M, Del Gaudio M, Gardini A, Cescon M, Varotti G, Cetta F, Cavallari A (2003) Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence. Ann Surg 237:536–543 64. Koo J, Fung K, Siu KF, Lee NW, Lett Z, Ho J, Wong J, Ong GB (1983) Recovery of malig-nant tumor cells from the right atrium during hepatic resection for hepatocellular carcinoma. Cancer 52:1952–1956 65. Portolani N, Coniglio A, Ghidoni S, Giovanelli M, Benetti A, Tiberio GA, Giulini SM (2006) Early and late recurrence after liver resection for hepatocellular carcinoma: prognostic and therapeutic implications. Ann Surg 243:229–235 66. Shirabe K, Kanematsu T, Matsumata T, Adachi E, Akazawa K, Sugimachi K (1991) Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses. Hepatology 14:802–805 15 Vascular Resection for Hepatocellular Carcinoma 259 67. Vauthey JN, Lauwers GY, Esnaola NF, Do KA, Belghiti J, Mirza N, Curley SA, Ellis LM, Regimbeau JM, Rashid A, Cleary KR, Nagorney DM (2002) Simplified staging for hepatocellular carcinoma. J Clin Oncol 20:1527–1536 68. Nanashima A, Sumida Y, Abo T, Nagasaki T, Ohba K, Kinoshita H, Tobinaga S, Kenji T, Takeshita H, Hidaka S, Sawai T, Yasutake T, Nagayasu T (2008) Surgical treatment and adju-vant chemotherapy in hepatocellular carcinoma patients with advanced vascular involvement. Hepatogastroenterology 55:627–632 ... - tailieumienphi.vn