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Exp Clin Transplant 7:13–17 93. Guba M, Steinbauer M, Ruhland V et al (2002) Elevated MIA serum levels are predictors of poor prognosis after surgical resection of metastatic malignant melanoma. Oncol Reports 9:981–984 94. Schumacher G, Oidtmann M, Rosewicz S et al (2002) Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth. Transplant Proc 34:1392–1393 95. Kneteman NM, Oberholzer J, Al Saghier M et al (2004) Sirolimus-based immunosuppression for liver transplantation in the presence of extended criteria for hepatocellular carcinoma. Liver Transpl 10:1301–1311 96. Marsh JW, Finkelstein SD, Demetris AJ et al (2003) Genotyping of hepatocellular carcinoma in liver transplant recipients adds predictive power for determining recurrence-free survival. Liver Transpl 9:664–671 97. UNOS/OPTN policy 3.6.4.4. http://www.optn.org. Accessed November 2009 Chapter 15 Vascular Resection for Hepatocellular Carcinoma Robin D. Kim and Alan W. Hemming Keywords Vascular resection · Vascular reconstruction · HCC · Intraoperative strategies for hepatic/vascular resections · Ante situm procedure Introduction Liver surgery has progressed over the last two decades to become a distinct area of specialization. Strategies such as portal vein embolization (Chapter 11) to induce growth of the planned liver remnant permit more aggressive resections, and improved imaging allows the surgeon to assess tumor position in relation to the intrahepatic vasculature. Liver transplantation has also progressed, but has been limited by the shortage of cadaveric donors. The development of live donor liver transplantation in response to this organ shortage has, in turn, led to techniques that can also be applied in non-transplant liver surgery. Resection and reconstruction of portal vein, hepatic artery, bile duct, and hepatic veins, all standard components of live donor liver transplantation, can be used in resecting complex HCC lesions by surgeons experienced in techniques developed for both liver resection and trans-plantation. Vascular resection and reconstruction is utilized to both achieve adequate oncologic tumor clearance and also preserve uninvolved hepatic parenchyma when vascular inflow or outflow is involved. In this chapter, we examine the role and techniques of vascular resection and reconstruction for HCC. A.W. Hemming ( ) Division of Transplantation and Hepatobiliary Surgery, Department of Surgery, University of California, San Diego, CA, USA K.M. McMasters, J.-N. Vauthey (eds.), Hepatocellular Carcinoma, 239 DOI 10.1007/978-1-60327-522-4_15, C Springer Science+Business Media, LLC 2011 ... - tailieumienphi.vn
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