Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis
Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis
Although the pathogenesis of paediatric-onset autoimmune hepatitis (pAIH) remains incompletely understood, genetic variants and environmental factors are known to be involved. Caspase recruitment domain family member 10 (CARD10) is a scaffold protein that participates in a complex pathway activating nuclear factor kappa-B (NFjB) and tumour necrosis factor alpha (TNF-a). This study aimed to investigate the association of CARD10 rs6000782 (g.37928186A > C) and TNF gene promoter rs1799724 (c.-1037C