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Antiarrhythmic Drugs
A practical guide
SECOND EDITION
Richard N. Fogoros, M.D. Pittsburgh, PA
2007 Richard Fogoros Published by Blackwell Publishing
Blackwell Futura is an imprint of Blackwell Publishing
Blackwell Publishing, Inc., 350 Main Street, Malden, Massachusetts 02148-5020, USA Blackwell Publishing Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UK
Blackwell Science Asia Pty Ltd, 550 Swanston Street, Carlton, Victoria 3053, Australia
All rights reserved. No part of this publication may be reproduced in any form or by any electronic or mechanical means, including information storage and retrieval systems, without permission in writing from the publisher, except by a reviewer who may quote brief passages in a review.
First published 1997 Second edition 2007
1 2007
ISBN: 978-1-4051-6351-4
Library of Congress Cataloging-in-Publication Data
Fogoros, Richard N.
Antiarrhythmic Drugs : a practical guide / Richard N. Fogoros. – 2nd ed. p. ; cm.
Includes bibliographical references and index. ISBN 978-1-4051-6351-4 (alk. paper)
1. Myocardial depressants. 2. Arrhythmia–Chemotherapy. I. Title. [DNLM: 1. Anti-Arrhythmia Agents. 2. Arrhythmia–drug therapy.
QV 150 F656a 2007]
RM347.F64 2007 616.128061–dc22
2007005643
A catalogue record for this title is available from the British Library
Set in Meridien 9.25/12pt by Aptara Inc., New Delhi, India Printed and bound in Singapore by Markono Print Media Pte Ltd
Commissioning Editor: Gina Almond Development Editor: Fiona Pattison Editorial Assistant: Victoria Pitman
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The publisher’s policy is to use permanent paper from mills that operate a sustainable forestry policy, and which has been manufactured from pulp processed using acid-free and elementary chlorine-free practices. Furthermore, the publisher ensures that the text paper and cover board used have met acceptable environmental accreditation standards.
Blackwell Publishing makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check that any product mentioned in this publication is used in accordance with the prescribing information prepared by the manufacturers. The author and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this book.
Contents
Preface, v
Aknowledgments, viii
Part 1 Basic principles
Chapter 1 Mechanisms of cardiac tachyarrhythmias, 3
Chapter 2 Introduction to antiarrhythmic drugs, 36
Part 2 Clinical features of antiarrhythmic drugs
Chapter 3 Class I antiarrhythmic drugs, 55
Chapter 4 Class II antiarrhythmic drugs; beta-blocking agents, 80
Chapter 5 Class III antiarrhythmic drugs, 86
Chapter 6 Class IV drugs: calcium-blocking agents, 102
Chapter 7 Unclassified antiarrhythmic agents, 107
Chapter 8 Investigational antiarrhythmic drugs, 112
Chapter 9 Common adverse events with antiarrhythmic drugs, 117
Part 3 Antiarrhythmic drugs in the treatment of cardiac arrhythmias
Chapter 10 Basic principles of using antiarrhythmic drugs, 133
Chapter 11 Treatment of supraventricular tachyarrhythmias, 138
iii
iv Contents
Chapter 12 Treatment of ventricular arrhythmias, 151
Chapter 13 Treatment of arrhythmias in pregnancy, 164
Index, 169
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