Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer
Deletion of TRIB3 disrupts the tumor progression induced by integrin αvβ3 in lung cancer
Integrin αvβ3 has been proposed as crucial determinant for tumor sustained progression and a molecular marker for the estimation of tumor angiogenesis. Our study suggested that integrin αvβ3 could efficiently promote lung cancer cell proliferation and stem-like phenotypes in a tribbles homolog 3 (TRIB3) dependent manner.