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handbook of Drug Data tenth edition EDITORS Philip O. Anderson, PharmD, FASHP, FCSHP Director, Drug Information Service, Department of Pharmacy University of California Medical Center, San Diego, California Clinical Professor of Pharmacy University of California, San Francisco San Diego Program, San Diego, California James E. Knoben, PharmD, MPH Drug Information Officer Special Assistant to Associate Director for Specialized Information Services National Library of Medicine National Institutes of Health Baltimore, Maryland William G. Troutman, PharmD, FASHP Regents’ Professor of Pharmacy, College of Pharmacy University of New Mexico, Albuquerque, New Mexico MCGRAW-HILL Medical Publishing Division New York Mexico City Toronto Chicago San Francisco Lisbon Milan New Delhi San Juan Seoul London Madrid Singapore Sydney Notice Medicine is an ever-changing science. As new research and clinical expe-rience broaden our knowledge, changes in treatment and drug therapy are required. The authors and the publisher of this work have checked with sources believed to be reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication. However, in view of the possibility of human error or changes in medical sciences, neither the authors nor the publisher nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect ac-curate or complete, and they disclaim all responsibility for any errors or omissions or for the results obtained from use of such information. Read-ers are encouraged to confirm the information contained in this work. For example and in particular, readers are advised to check the product infor-mation sheet included in the package of each drug they plan to administer to be certain that the information contained in this work is accurate and that changes have not been made in the recommended dose or in the con-traindications for administration. This recommendation is of particular importance in connection with new or infrequently used drugs. NOTICE: The editors, Philip O. Anderson, PharmD, James E. Knoben, PharmD, and William G. Troutman, PharmD, and the contributors have written this book in our pri-vate capacities. No official support or endorsement by any university, hospital, federal agency, or pharmaceutical company is intended or should be inferred. HANDBOOK OF CLINICAL DRUG DATA, 10TH EDITION Copyright © 2002 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in the United States of America. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval sys-tem, without the prior written permission of the publisher. 1 2 3 4 5 6 7 8 9 0 DOC DOC 0 9 8 7 6 5 4 3 2 1 ISBN 0-07-136362-9 This book was set in Times Roman at Pine Tree Composition, Inc. The editors were Stephen Zollo and Nicky Panton. The production supervisor was Richard Ruzycka. The cover designer was Janice Bielawa. The index was prepared by Jerry Ralya. R.R. Donnelley and Sons Company was printer and binder. This book is printed on acid-free paper. Library of Congress Cataloging-in-Publication Data Handbook of clinical drug data.—10th ed. / [edited by] Philip Anderson, James Knoben, William Troutman. p.; cm. Includes index. ISBN 0-07-136362-9 1. Pharmacology—Handbooks, manuals, etc. 2. Drugs—Handbooks, manuals, etc. I. Title: Handbook of Clinical drug data. II. Anderson, Philip O. III. Knoben, James E. IV. Troutman, William G. [DNLM: 1. Pharmaceutical Preparations—Handbooks. 2. Pharmacology, Clinical—Handbooks. QV 39 H2358 2001] RM301.12.H36 2001 615¢ .1—dc21 00-054887 INTERNATIONAL EDITION ISBN 112445-4 Copyright © 2002. Exclusive rights by the McGraw-Hill Companies, Inc., for manufacture and export. This book cannot be reexported from the country to which it is consigned by McGraw-Hill. The International Edition is not available in North America. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xiii How to Use This Book . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..xv PART I DRUG MONOGRAPHS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Principal Editor: Philip O. Anderson, PharmD Analgesic and Anti-inflammatory Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Antimigraine Drugs, Toy S. Biederman, PharmD . . . . . . . . . . . . . . . . . . . . . . 3 Antirheumatic Drugs, Stephen M. Setter, PharmD, DVM, Danial E. Baker, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Nonsteroidal Anti-inflammatory Drugs, Stephen M. Setter, PharmD, DVM, Danial E. Baker, PharmD . . . . . . . . . . . . . . . . . . . . . . . . 16 Opioids, Mark T. Holdsworth, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Antimicrobial Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .55 Aminoglycosides, Renée-Claude Mercier, PharmD . . . . . . . . . . . . . . . . . . . . . . 55 Antifungal Drugs, Polly E. Kintzel, PharmD, Philip O. Anderson, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 Antimycobacterial Drugs, Craig R. Ballard, PharmD . . . . . . . . . . . . . . . . . . . . 82 Antiparasitic Drugs, Philip O. Anderson, PharmD . . . . . . . . . . . . . . . . . . . . . . . 93 Antiviral Drugs, Craig R. Ballard, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 b-Lactams, Renée-Claude Mercier, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . 126 Macrolides, Craig R. Ballard, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 Quinolones, Renée-Claude Mercier, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . 166 Sulfonamides, Craig R. Ballard, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 Tetracyclines, Philip O. Anderson, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . 175 Miscellaneous Antimicrobials, Renée-Claude Mercier, PharmD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Antineoplastics, Chemoprotectants, and Immunosuppressants . . . . . . . . . . . . . . .204 Antineoplastics, Robert T. Dorr, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 Alkylating Agents, Robert T. Dorr, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 Antimetabolites, Robert T. Dorr, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 Cytokines, Robert T. Dorr, PhD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233 DNA Intercalating Drugs, Robert T. Dorr, PhD . . . . . . . . . . . . . . . . . . . . . . . . 237 v ... - tailieumienphi.vn
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