Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874

Diabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient of Psoralea corylifolia Linn. (PCL), which was used to treat a number of diseases

8/28/2020 11:26:14 PM +00:00

Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole

The pharmacokinetics of proton pump inhibitors (PPIs) may be affected by food intake. We aimed to evaluate the effect of food on the pharmacokinetics of omeprazole, rabeprazole, and pantoprazole.

8/28/2020 11:26:06 PM +00:00

Oral intermittent vitamin D substitution: Influence of pharmaceutical form and dosage frequency on medication adherence: A randomized clinical trial

To assess adherence to and preference for vitamin D substitution with different pharmaceutical forms and frequencies of administration.

8/28/2020 11:25:58 PM +00:00

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences.

8/28/2020 11:25:50 PM +00:00

Influence of strengthened hemoperfusion combined with continuous venovenous hemofiltration on prognosis of patients with acute paraquat poisoning: SHP + CVVH improve prognosis of acute PQ patients

The success rate of rescue is extremely low in acute paraquat poisoning. This study aimed to assess whether strengthened hemoperfusion (SHP) combined with continuous venovenous hemofiltration (CVVH) improves prognosis in patients with acute paraquat poisoning.

8/28/2020 11:25:42 PM +00:00

Clinical efficacy and safety in patients treated with teicoplanin with a target trough concentration of 20 μg/mL using a regimen of 12 mg/kg for five doses within the initial 3 days

A trough concentration (Cmin) ≥20 μg/mL of teicoplanin is recommended for the treatment of serious methicillin-resistant Staphylococcus aureus (MRSA) infections. However, sufficient clinical evidence to support the efficacy of this target Cmin has not been obtained.

8/28/2020 11:25:34 PM +00:00

Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin.

8/28/2020 11:25:26 PM +00:00

Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: A case report and literature review

Solitary metastasis of a malignancy to the spleen is rare, particularly for gastric cancer. Only a few case reports have documented isolated splenic metastasis from early gastric cancer. We describe a case of splenic metastasis from early gastric cancer.

8/28/2020 11:25:17 PM +00:00

Depletion of p21-activated kinase 1 upregulates the immune system of APCΔ14/+ mice and inhibits intestinal tumorigenesis

P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil.

8/28/2020 11:25:09 PM +00:00

Retinal and vitreous metastases from hepatocholangiocarcinoma

To report a case of metastatic hepatocholangiocarcinoma to the vitreous and retina. A 70-year-old male, who was recently diagnosed with hepatocholangiocarcinoma, was complaining of floaters in his right eye over the past 5 months and was referred to the Liverpool Ocular Oncology Centre.

8/28/2020 11:25:01 PM +00:00

Personalised informed choice on evidence and controversy on mammography screening: Study protocol for a randomized controlled trial

In Italy women aged 50–69 are invited for a population-based breast cancer (BC) screening. Physicians, policy makers and patients associations agree on the need to inform women about the benefits and harms in order to permit an informed decision.

8/28/2020 11:24:52 PM +00:00

HPV and cofactors for invasive cervical cancer in Morocco: A multicentre casecontrol study

Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub-types of cervical cancer in Morocco and investigate risk factors for this disease.

8/28/2020 11:24:44 PM +00:00

Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients

During posttreatment surveillance of head and neck cancer patients, imaging is insufficiently accurate for the early detection of relapsing disease. Free circulating tumor DNA (ctDNA) may serve as a novel biomarker for monitoring tumor burden during posttreatment surveillance of these patients.

8/28/2020 11:24:36 PM +00:00

African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks

Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency.

8/28/2020 11:24:27 PM +00:00

A phase 2 randomized trial to evaluate the impact of a supervised exercise program on cardiotoxicity at 3 months in patients with HER2 overexpressing breast cancer undergoing adjuvant treatment by trastuzumab: Design of the CARDAPAC study

The overexpression of human epidermal growth factor receptor-2 (HER2) in breast cancer is a poor prognosis. Trastuzumab improves overall survival but is associated with cardiotoxicity, especially a decline in left ventricular ejection fraction (LVEF).

8/28/2020 11:24:19 PM +00:00

Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through routes that involve invasion of the choroid, sclera and optic nerve or more broadly via the ocular vasculature.

8/28/2020 11:24:10 PM +00:00

Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion.

8/28/2020 11:24:01 PM +00:00

Anaplastic astrocytoma mimicking progressive multifocal leucoencephalopathy: A case report and review of the overlapping syndromes

Co-occurrence of multiple sclerosis (MS) and glial tumours (GT) is uncommon although occasionally reported in medical literature. Interpreting the overlapping radiologic and clinical characteristics of glial tumours, MS lesions, and progressive multifocal leukoencephalopathy (PML) can be a significant diagnostic challenge.

8/28/2020 11:23:53 PM +00:00

The dose-response relationship between tobacco smoking and the risk of lymphomas: A case-control study

Previous studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship.

8/28/2020 11:23:45 PM +00:00

Breast cancer patient delay in Fukushima, Japan following the 2011 triple disaster: A long-term retrospective study

Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk of experiencing patient delay among breast cancer patients in an area affected by the 2011 triple disaster in Fukushima, Japan, and to elucidate factors associated with post-disaster patient delay.

8/28/2020 11:23:36 PM +00:00