SYNTHETIC MULTIVALENT MOLECULES. This book presents basic and advanced principles underlying the multivalent interactions that are prevalent in biological systems. To illustrate important or complex concepts, the book provides up-to-date examples of synthetic multivalent molecules, their design, and their biological benefits. Functional roles displayed by such molecules of both natural and synthetic origin are well documented in biology, where they exert unique and crucial activities at a level not readily achievable by monovalent molecules. The concept of multivalent design is now accepted as an e¤ective strategy—in particular, for designing ligands, inhibitors, and drugs that influence biological systems potently and selectively..... Cũng như các thư viện tài liệu khác được bạn đọc giới thiệu hoặc do sưu tầm lại và chia sẽ lại cho các bạn với mục đích nâng cao trí thức , chúng tôi không thu phí từ người dùng ,nếu phát hiện tài liệu phi phạm bản quyền hoặc vi phạm pháp luật xin thông báo cho website ,Ngoài tài liệu này, bạn có thể download bài giảng miễn phí phục vụ nghiên cứu Vài tài liệu tải về mất font không hiển thị đúng, nguyên nhân máy tính bạn không hỗ trợ font củ, bạn tải các font .vntime củ về cài sẽ xem được.
SYNTHETIC MULTIVALENT MOLECULES
SYNTHETIC MULTIVALENT MOLECULES
Concepts and Biomedical Applications
A JOHN WILEY & SONS, INC., PUBLICATION
Copyright 6 2004 by John Wiley & Sons, Inc. All rights reserved.
Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published simultaneously in Canada.
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Library of Congress Cataloging-in-Publication Data:
Choi, Seok-ki, 1964–
Synthetic multivalent molecules : concepts and biomedical applications / Seok-ki Choi.
p. cm. Includes index.
ISBN 0-471-56347-1 (cloth)
1. Multivalent molecules—Synthesis. 2. Multivalent molecules—Design. 3. Multivalent molecules—Physiological e¤ect. I. Title.
RS431.M84 C48 2004 6150.31—dc22
Printed in the United States of America
10 9 8 7 6 5 4 3 2 1
Notes for Organization and Classiﬁcation xxi
1 Introduction 1
1.1 Nomenclature and Deﬁnitions, 1 1.1.1 Valency, 1
1.1.2 Linkers, 3 1.1.3 Sca¤olds, 4
1.1.4 Ligand Density, 7
1.1.5 Homo- and Heterovalent Molecules, 7
1.2 Mechanistic Aspects of Multivalent Interaction, 9 1.2.1 A‰nity Constant and Avidity, 9
1.2.2 Thermodynamics, 12 1.2.3 Kinetics, 18
1.2.4 Steric E¤ects, 19
1.3 Biological Roles of Multivalent Ligands, 20
2 Multivalent Molecules Applied to Viral Targets 23
2.1 Inﬂuenza Virus, 23
2.1.1 Hemagglutinin, 23
126.96.36.199 Divalent Sialic Acid, 23 188.8.131.52 Tetravalent Sialoside, 26
184.108.40.206 Dendrimers Presenting Sialosides, 26