PROTEIN PHOSPHORYLATION IN HUMAN HEALTH

PROTEIN PHOSPHORYLATION IN HUMAN HEALTH Edited by Cai Huang PROTEIN PHOSPHORYLATION IN HUMAN HEALTH Edited by Cai Huang Protein Phosphorylation in Human Health http://dx.doi.org/10.5772/2944 Edited by Cai Huang Contributors Elena Tchevkina, Andrey Komelkov, Andrei V. Budanov, Björn Stork, Sebastian Alers, Antje S. Löffler, Sebastian Wesselborg, Jing Pu, Pingsheng Liu, Olga Calvo, Alicia García, Martin Lützelberger, Norbert F. Käufer, Katrin Deinhardt, Freddy Jeanneteau, Andres Joaquin Lopez-Contreras, Oscar Fernandez-Capetillo, Dmytro Pavlov, John G. Mielke, Nina Kurrle, Bincy John, Melanie Meister, Ritva Tikkanen, Masataka Oda, Masahiro Nagahama, Keiko Kobayashi, Jun Sakurai, Yamuna D. Gandaharen, Rachel S. Welt, David Kostyal, Sydney Welt, Roberta Fraschini, Erica Raspelli, Corinne Cassani, C. Frazer, P.G. Young, Shuishu Wang Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Vedran Greblo Typesetting InTech Prepress, Novi Sad Cover InTech Design Team First published September, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Protein Phosphorylation in Human Health, Edited by Cai Huang p. cm. ISBN 978-953-51-0737-8 Contents Preface IX Section 1 Chapter 1 Akt, mTOR and AMPK in Cancer and Metabolic Disorders 1 Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways 3 Elena Tchevkina and Andrey Komelkov Chapter 2 Sestrins Link Tumor Suppressors with the AMPK-TOR Signaling Network 51 Andrei V. Budanov Chapter 3 Regulation of Autophagy by Protein Phosphorylation 97 Björn Stork, Sebastian Alers, Antje S. Löffler and Sebastian Wesselborg Chapter 4 Section 2 Chapter 5 Chapter 6 Chapter 7 Fatty Acids Stimulate Glucose Uptake by the PI3K/AMPK/Akt and PI3K/ERK1/2 Pathways 129 Jing Pu and Pingsheng Liu Protein Phosphorylation in Transcription, pre-mRNA Splicing and DNA Damage 149 RNA Polymerase II Phosphorylation and Gene Expression Regulation 151 Olga Calvo and Alicia García The Prp4 Kinase: Its Substrates, Function and Regulation in Pre-mRNA Splicing 195 Martin Lützelberger and Norbert F. Käufer More Than Just an OFF-Switch: The Essential Role of Protein Dephosphorylation in the Modulation of BDNF Signaling Events 217 Katrin Deinhardt and Freddy Jeanneteau ... - tailieumienphi.vn